1. The dramatic reaction below was reported in the Evans synthesis of colchicine in 1981. MeO CO₂Me -CO₂Me OH MeO OMe CF3CO₂H MeO 5 3 OMe MeO OMe OMe A. Label reactant carbon atoms 1-7 in the product and circle the single bond made in the product through an electrophilic aromatic substitution process. B. Add curved arrows and a reactive intermediate below to show how the starting materials of this reaction convert to intermediate A via 1. pt; 2. [AE + SN2]. CO₂Me OH MeO. OMe MeO F3CCO₂ H [AE + SN2] OMe pt MeO MeO OMe A -CO₂Me -OH OH OMe -O₂CCF3

1. The dramatic reaction below was reported in the Evans synthesis of colchicine in 1981. MeO CO₂Me -CO₂Me OH MeO OMe CF3CO₂H MeO 5 3 OMe MeO OMe OMe A. Label reactant carbon atoms 1-7 in the product and circle the single bond made in the product through an electrophilic aromatic substitution process. B. Add curved arrows and a reactive intermediate below to show how the starting materials of this reaction convert to intermediate A via 1. pt; 2. [AE + SN2]. CO₂Me OH MeO. OMe MeO F3CCO₂ H [AE + SN2] OMe pt MeO MeO OMe A -CO₂Me -OH OH OMe -O₂CCF3

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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