1. Ion exchange resin is commonly used for purification of pharmaceutical products from a cell lysate (liquid solution). The surface area is an important consideration as it reflects the amount of product that can be adsorbed to the resin. A packed bed of spherical resin particles (see figure below) has a bulk density of 0.650 g/cm³ and a density of 1.12 g/cm³. Calculate the specific surface area of a resin particle (in µm²/m³), porosity of the packed bed, and the specific surface area of the packed bed (in m²/m³). O} D = 100 μm

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What would be the total surface area (in m2) of the ion exchange resin in problem 1 if a 2.50 L
packed column (total volume) was used for purification? 

1. Ion exchange resin is commonly used for purification of pharmaceutical products from a cell
lysate (liquid solution). The surface area is an important consideration as it reflects the amount
of product that can be adsorbed to the resin. A packed bed of spherical resin particles (see figure
below) has a bulk density of 0.650 g/cm³ and a density of 1.12 g/cm³. Calculate the specific
surface area of a resin particle (in µm²/m³), porosity of the packed bed, and the specific
surface area of the packed bed (in m²/m³).
OF
D = 100 μm
Transcribed Image Text:1. Ion exchange resin is commonly used for purification of pharmaceutical products from a cell lysate (liquid solution). The surface area is an important consideration as it reflects the amount of product that can be adsorbed to the resin. A packed bed of spherical resin particles (see figure below) has a bulk density of 0.650 g/cm³ and a density of 1.12 g/cm³. Calculate the specific surface area of a resin particle (in µm²/m³), porosity of the packed bed, and the specific surface area of the packed bed (in m²/m³). OF D = 100 μm
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