Answered: 1. For the pH 4.5 buffer, you must use…

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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A generic version for Drug X is applying registration to the FDA. For the generic drug to be approved, it must prove bioequivalence with an innovator/originator drug. However, the company registering Drug X is applying for an exemption for in vivo bioequivalence testing. To qualify for this exemption, one of the requirements is to prove that it can be highly soluble in an aqueous buffer of pH 1.2, 4.5, 6.8. As the drug formulator, you need to prepare these buffers to test your sample. 1. For the pH 4.5 buffer, you must use acetic acid and sodium hydroxide: CH3COOH + NaOH → NaCH3COO + H2O The Ka of acetic acid is 1.8 x 10-5. Using the Henderson-Hasselbalch equation, calculate the molar ratio of [conjugate base]/[weak acid] that must be used in preparing the buffer. 0.29 B. 0.57 C. 0.87 D. 1.14 2. The only remaining NaOH in the lab is 100 mL of 1.0 M NaOH solution. Given this amount, how many moles of acetic acid must be used to prepare 1 L of the buffer. 0.088 mol B. 0.175 mol C. 0.275 mol D. 0.350 mol 3. If the lab has an available stock of 5.0 M acetic acid solution, how many mL of this solution must be used to obtain the calculated moles of acetic acid? 17.6 mL B. 35.0 mL C. 55.0 mL D. 70.0 mL 4. Using the Van Slyke equation, calculate the buffer capacity, B, of the buffer to be prepared. 0.100 B. 0.146 C. 0.200 D. 0.235

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