1. Cetrizine is a nonsedating antihistamine. The first step in a synthesis of cetirizine involves the following Grignard reaction. Give the major product and propose a reasonable mechanism for the following reaction: H CI 1) 2) HCI, H₂O MgBr , diethyl ether
1. Cetrizine is a nonsedating antihistamine. The first step in a synthesis of cetirizine involves the following Grignard reaction. Give the major product and propose a reasonable mechanism for the following reaction: H CI 1) 2) HCI, H₂O MgBr , diethyl ether
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter22: Reactions Of Benzene And Its Derivatives
Section: Chapter Questions
Problem 22.46P
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![1. Cetrizine is a nonsedating antihistamine. The first step in a synthesis of cetirizine
involves the following Grignard reaction. Give the major product and propose a reasonable
mechanism for the following reaction:
H
CI
1)
2) HCI, H₂O
MgBr
diethyl ether](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fbb9b9938-839f-424a-9dbd-e1a4bc82fcd7%2Ff9b4918e-fa86-4d5d-b368-c150513d5f45%2Fsnc0c8_processed.jpeg&w=3840&q=75)
Transcribed Image Text:1. Cetrizine is a nonsedating antihistamine. The first step in a synthesis of cetirizine
involves the following Grignard reaction. Give the major product and propose a reasonable
mechanism for the following reaction:
H
CI
1)
2) HCI, H₂O
MgBr
diethyl ether
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