1. Cetrizine is a nonsedating antihistamine. The first step in a synthesis of cetirizine involves the following Grignard reaction. Give the major product and propose a reasonable mechanism for the following reaction: H CI 1) 2) HCI, H₂O MgBr , diethyl ether

1. Cetrizine is a nonsedating antihistamine. The first step in a synthesis of cetirizine involves the following Grignard reaction. Give the major product and propose a reasonable mechanism for the following reaction: H CI 1) 2) HCI, H₂O MgBr , diethyl ether

Chemistry

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ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

1. Cetrizine is a nonsedating antihistamine. The first step in a synthesis of cetirizine
involves the following Grignard reaction. Give the major product and propose a reasonable
mechanism for the following reaction:
H
CI
1)
2) HCI, H₂O
MgBr
diethyl ether

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