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1. A daily low dosage of aspirin (acetylsalicylic acid) can lower the risk of heart attack and stroke for individuals at risk. Aspirin suppresses the generation of prostaglandins by irreversible binding to the enzyme COX-1. Inhibition of prostaglandin synthesis lowers the production of thromboxanes that are responsible for the aggregation of platelets and the formation of blood clots. You will explore the mechanism of aspirin binding. 1.1 The average pH of the human body is 7.4 (also known as a physiological pH). Draw the structure of aspirin at a physiological pH. OH 1.2 Aspirin reacts with the amino acid Serine. What is the structure of serine? Draw the structure of the tripeptide Ala-Ser-Trp (draw these structures as they exist at physiological pH) serine Ala-Ser-Trp 1.3 Aspirin reacts with Serine 530 of COX-1 by transesterification reaction. Draw a general mechanism of acid-catalyzed transesterification reaction. Use HA as an acid. 1.4 Draw an arrow-pushing mechanism for the reaction between aspirin and a serine residue. Use the explicit structure of aspirin. complete arrow-pushing aspirin HO serine 530 tetrahedral intermidiate products 1.5 Many people store aspirin inside a 'medicine cabinet' in the bathroom. Is it a good idea to store aspirin in a high-humidity environment? Use your knowledge of Fischer esterification to predict the possible outcome of the reaction between aspirin and water. Draw the products of the reaction and explain why this would happen. products Explanation:

1. A daily low dosage of aspirin (acetylsalicylic acid) can lower the risk of heart attack and stroke for individuals at risk. Aspirin suppresses the generation of prostaglandins by irreversible binding to the enzyme COX-1. Inhibition of prostaglandin synthesis lowers the production of thromboxanes that are responsible for the aggregation of platelets and the formation of blood clots. You will explore the mechanism of aspirin binding. 1.1 The average pH of the human body is 7.4 (also known as a physiological pH). Draw the structure of aspirin at a physiological pH. OH 1.2 Aspirin reacts with the amino acid Serine. What is the structure of serine? Draw the structure of the tripeptide Ala-Ser-Trp (draw these structures as they exist at physiological pH) serine Ala-Ser-Trp 1.3 Aspirin reacts with Serine 530 of COX-1 by transesterification reaction. Draw a general mechanism of acid-catalyzed transesterification reaction. Use HA as an acid. 1.4 Draw an arrow-pushing mechanism for the reaction between aspirin and a serine residue. Use the explicit structure of aspirin. complete arrow-pushing aspirin HO serine 530 tetrahedral intermidiate products 1.5 Many people store aspirin inside a 'medicine cabinet' in the bathroom. Is it a good idea to store aspirin in a high-humidity environment? Use your knowledge of Fischer esterification to predict the possible outcome of the reaction between aspirin and water. Draw the products of the reaction and explain why this would happen. products Explanation:

Chemistry for Today: General, Organic, and Biochemistry
Chemistry for Today: General, Organic, and Biochemistry
9th Edition
ISBN:9781305960060
Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Chapter19: Proteins
Section: Chapter Questions
Problem 19.71E
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1. A daily low dosage of aspirin (acetylsalicylic acid) can lower the risk of heart attack and stroke for individuals at risk. Aspirin suppresses the generation of prostaglandins by irreversible binding to the enzyme COX-1. Inhibition of prostaglandin synthesis lowers the production of thromboxanes that are responsible for the aggregation of platelets and the formation of blood clots. You will explore the mechanism of aspirin binding. 1.1 The average pH of the human body is 7.4 (also known as a physiological pH). Draw the structure of aspirin at a physiological pH. OH 1.2 Aspirin reacts with the amino acid Serine. What is the structure of serine? Draw the structure of the tripeptide Ala-Ser-Trp (draw these structures as they exist at physiological pH) serine Ala-Ser-Trp 1.3 Aspirin reacts with Serine 530 of COX-1 by transesterification reaction. Draw a general mechanism of acid-catalyzed transesterification reaction. Use HA as an acid. 1.4 Draw an arrow-pushing mechanism for the reaction between aspirin and a serine residue. Use the explicit structure of aspirin. complete arrow-pushing aspirin HO serine 530 tetrahedral intermidiate products 1.5 Many people store aspirin inside a 'medicine cabinet' in the bathroom. Is it a good idea to store aspirin in a high-humidity environment? Use your knowledge of Fischer esterification to predict the possible outcome of the reaction between aspirin and water. Draw the products of the reaction and explain why this would happen. products Explanation:
Transcribed Image Text:1. A daily low dosage of aspirin (acetylsalicylic acid) can lower the risk of heart attack and stroke for individuals at risk. Aspirin suppresses the generation of prostaglandins by irreversible binding to the enzyme COX-1. Inhibition of prostaglandin synthesis lowers the production of thromboxanes that are responsible for the aggregation of platelets and the formation of blood clots. You will explore the mechanism of aspirin binding. 1.1 The average pH of the human body is 7.4 (also known as a physiological pH). Draw the structure of aspirin at a physiological pH. OH 1.2 Aspirin reacts with the amino acid Serine. What is the structure of serine? Draw the structure of the tripeptide Ala-Ser-Trp (draw these structures as they exist at physiological pH) serine Ala-Ser-Trp 1.3 Aspirin reacts with Serine 530 of COX-1 by transesterification reaction. Draw a general mechanism of acid-catalyzed transesterification reaction. Use HA as an acid. 1.4 Draw an arrow-pushing mechanism for the reaction between aspirin and a serine residue. Use the explicit structure of aspirin. complete arrow-pushing aspirin HO serine 530 tetrahedral intermidiate products 1.5 Many people store aspirin inside a 'medicine cabinet' in the bathroom. Is it a good idea to store aspirin in a high-humidity environment? Use your knowledge of Fischer esterification to predict the possible outcome of the reaction between aspirin and water. Draw the products of the reaction and explain why this would happen. products Explanation:
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