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Template strand CH3 1 CH3 t+3' The wrong nucleotide is incorporated during ATIY 5 DNA synthesis. 5' ČTA AGCT GAG GATTTG ACT C 3' LIii Newly synthesized strand CH3 CH3 5' t Near the site of the mismatched base, an enzyme cuts the sugar-phosphate backbone of the unmethylated strand. GATTTG A CT C icut CH3 CH3 3 5' An enzyme degrades a short stretch of the strand ČŤÁ Á GČ ÍĞÁĞ GA 3' I стс ii 5 that had the error. CH3 CH3 T! 3 DNA polymerase synthesizes 5' GATTC G ACT C 3' a new stretch, incorporating ITLiİ5' the correct nucleotide. CH3 CH3 H 3' DNA ligase joins the 3' end of the newly synthesized segment to the original 5' strand. 3' DNA ligase FIGURE 8.10 Mismatch Repair +AT- -TAI -ATI * FATI -AT- TAL in 2. 4-

Template strand CH3 1 CH3 t+3' The wrong nucleotide is incorporated during ATIY 5 DNA synthesis. 5' ČTA AGCT GAG GATTTG ACT C 3' LIii Newly synthesized strand CH3 CH3 5' t Near the site of the mismatched base, an enzyme cuts the sugar-phosphate backbone of the unmethylated strand. GATTTG A CT C icut CH3 CH3 3 5' An enzyme degrades a short stretch of the strand ČŤÁ Á GČ ÍĞÁĞ GA 3' I стс ii 5 that had the error. CH3 CH3 T! 3 DNA polymerase synthesizes 5' GATTC G ACT C 3' a new stretch, incorporating ITLiİ5' the correct nucleotide. CH3 CH3 H 3' DNA ligase joins the 3' end of the newly synthesized segment to the original 5' strand. 3' DNA ligase FIGURE 8.10 Mismatch Repair +AT- -TAI -ATI * FATI -AT- TAL in 2. 4-

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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What role does methylation play in mismatch repair?

Template strand CH3 1 CH3 t+3' The wrong nucleotide is incorporated during ATIY 5 DNA synthesis. 5' ČTA AGCT GAG GATTTG ACT C 3' LIii Newly synthesized strand CH3 CH3 5' t Near the site of the mismatched base, an enzyme cuts the sugar-phosphate backbone of the unmethylated strand. GATTTG A CT C icut CH3 CH3 3 5' An enzyme degrades a short stretch of the strand ČŤÁ Á GČ ÍĞÁĞ GA 3' I стс ii 5 that had the error. CH3 CH3 T! 3 DNA polymerase synthesizes 5' GATTC G ACT C 3' a new stretch, incorporating ITLiİ5' the correct nucleotide. CH3 CH3 H 3' DNA ligase joins the 3' end of the newly synthesized segment to the original 5' strand. 3' DNA ligase FIGURE 8.10 Mismatch Repair +AT- -TAI -ATI * FATI -AT- TAL in 2. 4-
Transcribed Image Text:Template strand CH3 1 CH3 t+3' The wrong nucleotide is incorporated during ATIY 5 DNA synthesis. 5' ČTA AGCT GAG GATTTG ACT C 3' LIii Newly synthesized strand CH3 CH3 5' t Near the site of the mismatched base, an enzyme cuts the sugar-phosphate backbone of the unmethylated strand. GATTTG A CT C icut CH3 CH3 3 5' An enzyme degrades a short stretch of the strand ČŤÁ Á GČ ÍĞÁĞ GA 3' I стс ii 5 that had the error. CH3 CH3 T! 3 DNA polymerase synthesizes 5' GATTC G ACT C 3' a new stretch, incorporating ITLiİ5' the correct nucleotide. CH3 CH3 H 3' DNA ligase joins the 3' end of the newly synthesized segment to the original 5' strand. 3' DNA ligase FIGURE 8.10 Mismatch Repair +AT- -TAI -ATI * FATI -AT- TAL in 2. 4-
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