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Is paramutation a cis- or a trans-epigenetic mechanism?
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In epigenetic, paramutation is a phenomenon in which the expression of gene changes and that perticular gene is stably transmitted to their offsprings.
Or in other words
Paramutation is a epigenetic phenomenon that results in transferable epigenetic changes of gene regulation from parents to their offsprings.
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- "Tobacco smoking triggers a large number of somaticmutations and epigenetic changes". Define about this ?What is the key difference between cis- and trans-epigenetic mechanisms for maintaining an epigenetic modification? We considered genomic imprinting of the Igf2 gene, in whichoffspring express the copy of the gene they inherit from their father,but not the copy they inherit from their mother. Is this a cisora trans-epigenetic mechanism?Describe how epigenetic changes underlie paramutation.
- What are the main epigenetics mechanisms?In general, explain how epigenetic modifications are an important mechanism for developmental changes that lead to specialized body parts and cell types. How do the protein complexes called the trithorax and polycomb groups participate in this process?What makes X inactivation an epigenetic phenotype?
- A gene, which we will call gene C, can be epigenetically modified in such a way that its expression in some cells is permanently silenced. Describe how you could conduct cell-fusion experiments to determine if a cis- or a trans-epigenetic mechanism is responsible for maintaining the silencing of gene C.What are the three kinds of epigenetic mechanisms?Define the epigenetic mechanisms - reversible modification of DNA by the addition or removal of methyl groups ?
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