Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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![**Exercise: Identifying Chirality Centers in Amoxicillin**
In this exercise, you are asked to identify and circle the chirality centers in the structural formula of the compound Amoxicillin.
**Amoxicillin Structure:**
The diagram represents the molecular structure of Amoxicillin, a commonly used antibiotic. The structure includes various functional groups and a bicyclic ring system.
**Key Features:**
1. **Phenyl Group**: On the left side is a phenyl group (a benzene ring with a hydroxyl group, OH).
2. **Amide Group**: Linked to the phenyl group, featuring a carbonyl (C=O) attached to a nitrogen (NH2).
3. **Beta-lactam Ring**: Central to the structure, identifiable by a four-membered ring (square) composed of two carbons, an oxygen, and a nitrogen.
4. **Thiazolidine Ring**: A five-membered ring connected to the beta-lactam, including sulfur (S).
**Chirality Centers:**
- In organic chemistry, chirality centers (or stereocenters) are typically carbon atoms bonded to four different substituents. These centers are key to the optical activity of the molecule.
- In the diagram, **potential chirality centers** include:
- The carbon attached directly to the amine group (NH2) and part of the beta-lactam ring.
- The carbon connecting the beta-lactam and thiazolidine rings, forming a bridge between these rings.
By examining the molecular structure and identifying these centers, students can better understand the concept of chirality, which is critical for the biological activity of such compounds.
**Instruction:**
Circle the chirality centers on the diagram of Amoxicillin provided above.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F32bb3717-a6fb-4f58-b035-9d5406559919%2F169abf83-36ff-48ec-85ef-06c4d6a6ba03%2Fo7bjql5_processed.png&w=3840&q=75)
Transcribed Image Text:**Exercise: Identifying Chirality Centers in Amoxicillin**
In this exercise, you are asked to identify and circle the chirality centers in the structural formula of the compound Amoxicillin.
**Amoxicillin Structure:**
The diagram represents the molecular structure of Amoxicillin, a commonly used antibiotic. The structure includes various functional groups and a bicyclic ring system.
**Key Features:**
1. **Phenyl Group**: On the left side is a phenyl group (a benzene ring with a hydroxyl group, OH).
2. **Amide Group**: Linked to the phenyl group, featuring a carbonyl (C=O) attached to a nitrogen (NH2).
3. **Beta-lactam Ring**: Central to the structure, identifiable by a four-membered ring (square) composed of two carbons, an oxygen, and a nitrogen.
4. **Thiazolidine Ring**: A five-membered ring connected to the beta-lactam, including sulfur (S).
**Chirality Centers:**
- In organic chemistry, chirality centers (or stereocenters) are typically carbon atoms bonded to four different substituents. These centers are key to the optical activity of the molecule.
- In the diagram, **potential chirality centers** include:
- The carbon attached directly to the amine group (NH2) and part of the beta-lactam ring.
- The carbon connecting the beta-lactam and thiazolidine rings, forming a bridge between these rings.
By examining the molecular structure and identifying these centers, students can better understand the concept of chirality, which is critical for the biological activity of such compounds.
**Instruction:**
Circle the chirality centers on the diagram of Amoxicillin provided above.
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