. The following data describe the binding of oxygen to human myo- globin at 37 °C. Po, (mm Hg) Ро, (mm Hg) Yo, Yoz 0.5 0.161 0.697 1 0.277 8 0.754 2 0.434 12 0.821 3 0.535 20 0.885 4 0.605 From these data, estimate (a) Pg9 and (b) the fraction saturation of myoglobin at 30 mm Hg, the partial pressure of O, in venous blood. . What qualitative effect would you expect each of the following to have on the P50 of hemoglobin? (a) Increase in pH from 7.2 to 7.4 (b) Increase in Pco, from 20 to 40 mm Hg (c) Dissociation into monomer polypeptide chains

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. The following data describe the binding of oxygen to human myo-
globin at 37 °C.
Po, (mm Hg)
Ро, (mm Hg) Yo,
Yoz
0.5
0.161
0.697
1
0.277
8
0.754
2
0.434
12
0.821
3
0.535
20
0.885
4
0.605
From these data, estimate (a) Pg9 and (b) the fraction saturation of
myoglobin at 30 mm Hg, the partial pressure of O, in venous blood.
. What qualitative effect would you expect each of the following to
have on the P50 of hemoglobin?
(a) Increase in pH from 7.2 to 7.4
(b) Increase in Pco, from 20 to 40 mm Hg
(c) Dissociation into monomer polypeptide chains
Transcribed Image Text:. The following data describe the binding of oxygen to human myo- globin at 37 °C. Po, (mm Hg) Ро, (mm Hg) Yo, Yoz 0.5 0.161 0.697 1 0.277 8 0.754 2 0.434 12 0.821 3 0.535 20 0.885 4 0.605 From these data, estimate (a) Pg9 and (b) the fraction saturation of myoglobin at 30 mm Hg, the partial pressure of O, in venous blood. . What qualitative effect would you expect each of the following to have on the P50 of hemoglobin? (a) Increase in pH from 7.2 to 7.4 (b) Increase in Pco, from 20 to 40 mm Hg (c) Dissociation into monomer polypeptide chains
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