. How does Pravastatin work to produce the results presented in Table 1?   2. Which of the following statements are true about the results presented in Table 1? A. The study participants placed in the Prevastin intervention group had significantly higher total cholesterol levels. B. Pravastatin was effective at lowering LDL levels but had no impact on HDL levels. C. All study participants had average baseline LDL levels that are considered to be above the recommended or optimal level. D. The study participants that took the placebo experienced significant increases in their HDL levels.   3. Looking at the results presented in Table 2, how does Pravastatin work to have the reported impact on adverse cardiac events?

icon
Related questions
Question

Please answer the following questions based on study attached:

1. How does Pravastatin work to produce the results presented in Table 1?
 
2. Which of the following statements are true about the results presented in Table 1?
A. The study participants placed in the Prevastin intervention group had significantly higher total cholesterol levels.
B. Pravastatin was effective at lowering LDL levels but had no impact on HDL levels.
C. All study participants had average baseline LDL levels that are considered to be above the recommended or optimal level.
D. The study participants that took the placebo experienced significant increases in their HDL levels.
 
3. Looking at the results presented in Table 2, how does Pravastatin work to have the reported impact on adverse cardiac events?
 
4. True or False: Pravastatin was able to significantly reduce the risk of heart attack and stroke in those enrolled in the study. 
 
5. True of False: The study group taking Pravastatin saw a significant reduction of death from all causes while enrolled in this study. 
 
 
### Investigating the Health Impacts of Pravastatin

In several recent studies, the health impacts of Pravastatin, a statin, were measured over time. Study participants were randomized into two treatment groups, one that received a placebo and another that was prescribed Pravastatin. Cholesterol levels were measured in both groups over two years and summarized below.

#### Table 1. Plasma Cholesterol Levels at Baseline and During Trial

This table illustrates the various cholesterol levels (Total, HDL, and LDL) at different time intervals (0, 2, 12, and 24 months) with respective means, standard deviations, and p-values.

| Time Point | Total Cholesterol mg/dL (SD) |         | HDL Cholesterol mg/dL (SD) |           | LDL Cholesterol mg/dL (SD) |           |
|------------|------------------------------|---------|----------------------------|-----------|----------------------------|-----------|
|            | Pravastatin (n=450)          | Placebo (n=434) | P-value | Pravastatin (n=450) | Placebo (n=434) | P-value |
| 0 months   | 232.8 (33.26)                | 234.0 (33.26)   | 0.60    | 36.0 (8.89)         | 36.0 (8.89)      | 0.71    | 166.3 (30.16)        | 166.7 (30.16) | 0.74    |
| 2 months   | 182.5 (33.64)                | 239.0 (35.58)   | <.001   | 39.8 (9.28)         | 38.7 (8.51)      | <.001   | 114.1 (29.00)       | 167.8 (31.71) | <.001   |
| 12 months  | 186.4 (38.67)                | 239.0 (37.90)   | <.001   | 40.6 (9.72)         | 37.5 (8.69)      | <.001   | 117.6 (34.03)       | 167.8 (34.42) | <.001   |
| 24 months
Transcribed Image Text:### Investigating the Health Impacts of Pravastatin In several recent studies, the health impacts of Pravastatin, a statin, were measured over time. Study participants were randomized into two treatment groups, one that received a placebo and another that was prescribed Pravastatin. Cholesterol levels were measured in both groups over two years and summarized below. #### Table 1. Plasma Cholesterol Levels at Baseline and During Trial This table illustrates the various cholesterol levels (Total, HDL, and LDL) at different time intervals (0, 2, 12, and 24 months) with respective means, standard deviations, and p-values. | Time Point | Total Cholesterol mg/dL (SD) | | HDL Cholesterol mg/dL (SD) | | LDL Cholesterol mg/dL (SD) | | |------------|------------------------------|---------|----------------------------|-----------|----------------------------|-----------| | | Pravastatin (n=450) | Placebo (n=434) | P-value | Pravastatin (n=450) | Placebo (n=434) | P-value | | 0 months | 232.8 (33.26) | 234.0 (33.26) | 0.60 | 36.0 (8.89) | 36.0 (8.89) | 0.71 | 166.3 (30.16) | 166.7 (30.16) | 0.74 | | 2 months | 182.5 (33.64) | 239.0 (35.58) | <.001 | 39.8 (9.28) | 38.7 (8.51) | <.001 | 114.1 (29.00) | 167.8 (31.71) | <.001 | | 12 months | 186.4 (38.67) | 239.0 (37.90) | <.001 | 40.6 (9.72) | 37.5 (8.69) | <.001 | 117.6 (34.03) | 167.8 (34.42) | <.001 | | 24 months
Expert Solution
steps

Step by step

Solved in 5 steps

Blurred answer