Project SBI4U

docx

School

University of Ottawa *

*We aren’t endorsed by this school

Course

4U

Subject

Psychology

Date

Nov 24, 2024

Type

docx

Pages

3

Uploaded by maxinemowete

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PROJECT TOPIC STUDY: Importance of sleep in repairing DNA Primary Source: Sleep Improves Chromosome Dynamics to Enable the Reduction of Accumulating DNA Damage in Single Neurons Summary In March 2019, the Nature Communications journal released a research article titled "Sleep Increases Chromosome Dynamics to Enable Reduction of accumulating DNA damage in single neurons." The research article was curated by a group of academics and researchers with expertise in genetics and related subjects led by Israeli researcher David Zada. As mentioned in the publication's abstract, the journal's goal is to identify the primary biological role that sleep plays. The article outlines the comprehensive study methods and experiments, including imaging of zebrafish cells that were used to ascertain the role of sleep in nuclear maintenance and other restorative processes. The journal is fairly extensive and there are biological terminologies heavily used throughout the text. The paper concludes with the findings of the experimental study, which demonstrated that sleep boosts chromosomal dynamics in individual neurons but not in two other cell types. Additionally, they discovered that there is little chromosomal activity and that the quantity of double-strand breaks (DSBs) increases when a person is awake (Zada et al., 2019). In conclusion, Zada et al propose that sleep promotes chromosomal activities which are required to lower the number of double-strand breaks (damages) DNA experiences. REFERENCE Zada, D., Bronshtein, I. N., Lerer-Goldshtein, T., Garini, Y., & Appelbaum, L. (2019). Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons. Nature Communications , 10 (1). https://doi.org/10.1038/s41467-019-08806-w Secondary Source : Your brain may need sleep to repair DNA 'potholes' Summary The CBC online article "Your brain may need sleep to repair DNA 'potholes'" offers readers a summary of the research conducted to ascertain the significance of sleep for DNA preservation. The article has an interview with neurologist Dr. Lior Appelbaum, who explains the technical specifics of the study on the effects of sleep on individual neurons. Appelbaum points out that the research was done on fish, but he suggests that the results support the idea that sleep is
necessary in humans to facilitate DNA repair. A significant portion of the piece consists of quotes from this interview, which are followed by the author's analysis of how they understand Applebaum's conclusions. The article's author is unknown, making it difficult to determine their expertise in the biological field. Nonetheless, the author's analysis is without bias and provides a comprehensive summary of the extensive research that has been conducted in the field. They make use of catchy phrases and words such as "potholes" and "Zzzzz is universal" ( Your Brain May Need Sleep to Repair DNA “potholes” | CBC Radio , 2019) presumably to make the article more appealing and understandable for a general audience. In conclusion, even if the author of the piece is not identified, the piece is credible because it incorporates direct quotes from published studies and offers links to support its assertions. REFERENCES Your brain may need sleep to repair DNA “potholes” | CBC Radio . (2019, March 8). CBC. https://www.cbc.ca/radio/quirks/august-3-2019-science-of-awe-blue-whales-and- sonar-chromosomes-and-sleep-and-more-1.5047142/your-brain-may-need-sleep-to- repair-dna-potholes-1.5047151#:~:text=%22When%20you%20think%20about %20sleep,seemed%20to%20facilitate%20DNA%20repair.
REFLECTION This project aimed to examine the significance of utilizing primary and secondary sources in research and writing projects. To accomplish this, I opted to research the topic "Importance of sleep on DNA" using both types of sources. I used the study "Sleep Improves Chromosome Dynamics to Enable the Reduction of Accumulating DNA Damage in Single Neurons" as the primary source. This website can be considered an academic source because it offers a comprehensive overview of the research on the effects of sleep on DNA breakage and regeneration. It is published in the Journal of Nature Communications. Geneticists and other academics are the article's target audience. As a result, the article makes extensive use of biological and scientific vocabulary. Since Nature Communication magazine put this source through a thorough screening process before publishing, I determined this article to be one of the most reliable and authoritative on the subject matter. There is also a list of references provided at the end of the article which gives supporting evidence on the researchers’ arguments. It was quite challenging for me to understand the findings and technical terms, though, as I am not a specialist in the biological field. I had a difficult time comprehending the researchers' findings because the article was so technical. Fortunately, the research journal had an abstract that provided a thorough yet succinct summary of the study's methodology and conclusions. Nevertheless, it took me multiple readings of this paper and the definitions of numerous terms before I could comprehend and synthesize its conclusions. The same information is presented in a less technical manner than the academic source in the secondary source I selected, "Your brain may need sleep to repair DNA "potholes." In comparison to my academic source, the presentation style is less formal. It makes use of catchy language and glossy imagery. However, the article's author is not identified. Moreover, lists of pertinent literature or bibliographies are absent. Despite the author's ability to present unbiased and truthful information—including links to the studies carried out and a direct citation from a reputable neuroscientist—the piece's credibility was questionable. Nonetheless, the article provided me with a detailed analysis and interpretation of the extensive research that has been done on my subject matter thus providing me with ample material to augment my research study. In conclusion, both my research abilities and comprehension of primary and secondary materials have greatly improved. I now know how to assess a source's reliability before using it for research. In addition, I've discovered that the most effective approach to gathering reliable information for a topic is to combine primary and secondary sources. Although each source type has its flaws and benefits, they can be used complementarily to provide well-detailed research that is easily comprehended.
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