Oncology Worksheet _P4 Bootcamp

Oncology Worksheet 1. Using your RxPrep book, DiPiro, or your oncology notes, please provide definitions to the following words: a. Adjuvant – b. Malignant – c. Benign – d. Neoadjuvant – e. Induction therapy – f. Palliative – g. Staging – h. Curative – i. Consolidation therapy – j. Metastatic – k. Tumor markers –

2. Please complete the table for cancer screening. Please list all screening modalities and frequency. Cancer Gender Age Screening Modalities and Frequency Breast Cervical Colorectal Lung Prostate 3. Please provide 5 ways to lower your risk of skin cancer.

c. Breakthrough – d. Refractory – e. Anticipatory – 7. FC is a 69 yo male with a new diagnosis of B-cell lymphoma. He is to receive RCHOP. He is 72kg and 68inches. Please provide the dose the patient should receive for each drug. Please provide the emetic risk and an antiemetic prophylaxis regimen. The following is the regimen for RCHOP:  Rituximab 375mg/m 2 IV on day 1  Cyclophosphamide 7506mg/m 2 IV over 30 minutes on day 1  Doxorubicin 50mg/m 2 IV on Day 1  Vincristine 1.4mg/m 2 IV over 5-10 minutes on day 1  Prednisone 100mg PO daily on days 1-5

8. BF is a 65 yo male with a new diagnosis of leukemia. He has received induction therapy. Currently, his WBC is 1.2, his %bands is 12, and his %seg is 11. His hgb and hct are 8.9 and 29, respectively. His platelets are 8. What is his ANC? Is he neutropenic? Does he require blood transfusion or platelet transfusion? Why or why not? 9. SELECT ALL THAT APPLY. Unfortunately, BF develops a fever of 101. Blood cultures are drawn and a chest Xray was done. The internal medicine team would like to start antibiotics on him, but do not know what antibiotic. He doesn’t have any drug allergies and a history of MDR organisms. Which of the following antibiotics should be given to the patient? a. Nothing. The patient is not neutropenic. b. Cefepime c. Piperacillin/tazobactam d. Levofloxacin 10. Patients who have febrile neutropenia are at risk of _______________________ infections. 11. Please match the chemotherapy agent with the correct extravasation management. Each answer can be used more than once or may have multiple answers. A. Daunorubicin _____________ 1. DMSO B. Paclitaxel ______________ 2. Sodium thiosulfate C. Mitomycin ____________ 3. Heat D. Vinorelbine ___________ 4. Cold E. Mechlorethamine _____________ 5. Hyaluronnidase 6. Dexrazoxane

16. Please match the drug with the common side effect. Use each answer only once. A. Mitoxantrone _____ 1. GI perforation B. Oxaliplatin ______ 2. Heart failure C. Irinotecan ______ 3. Uterine cancer D. Anastrozole ______ 4. Peripheral neuropathy E. Tamoxifen ______ 5. VTE F. Bleomycin ______ 6. Osteoporosis G. Cisplatin _______ 7. Ototoxicity H. Paclitaxel _______ 8. Pulmonary fibrosis I. Thalidomide ______ 9. Cold induced peripheral neuropathy J. Bevacizumab ______ 10. Diarrhea 17. What are the max doses for the following drugs? Please complete the table. Drug Maximum dose Reason Bleomycin Doxorubicin Cisplatin Vincristine 18. Please provide the Pharmacogenomic consideration for each of the following agents: a. Capecitabine: b. Ado-trastuzumab emtansine: c. Pembrolizumab: d. Brigatinib: e. Irinotecan: f. Encorafenib: g. Imatinib:

h. Osimertinib: i. Crizotinib: 19. SELECT ALL THAT APPLY. Which of the following drugs require a REMS program for teratogenicity? a. Thalidomide b. Lenalidomide c. Bortezomib d. Blinatumomab 20. SELECT ALL THAT APPLY. Which agents require an ECHO or MUGA scan? a. Mitoxantrone b. Bevacizumab c. Arsenic oxide d. Trastuzumab 21. What are the signs and symptoms of tumor lysis syndrome? What are ways to manage tumor lysis syndrome? Please provide the side effects of each drug listed.