HSCI 101_Off Lab_Assignment 3_Fall 2023
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Medicine
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Dec 6, 2023
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Name: _______________________________
Bones and Bone Tissue
Complete the following questions
regarding the case study below.
A 10-year-old child is admitted to the hospital after complaining of sore ankles and knees. The patient, CJ, has polycystic kidney
disease (PKD), which is a genetic condition that has resulted in end-stage renal disease. The attending physician is concerned that
the bone pain may be related to their poor kidney function. To determine what is occurring, CJ is referred to a physician
specializing in orthopedics.
1.
The orthopedic physician is concerned about the long bones in CJ’s legs. Since CJ is only 10-years-old there is a possibility
that permanent damage the bones in their legs could affect their growth.
a.
Describe the structure and function of the periosteum, the perforating fibers, the endosteum, the diaphysis, and the
epiphyses.
b.
What are the differences between compact and spongy bone?
c.
What is the role of the epiphyseal plate, and what is the difference between the epiphyseal line? What do you think might
happen to CJ’s bones if the epiphyseal plates are damaged?
Renal osteodystrophy (ROD) is a bone disorder linked to chronic renal disease, in which renal disease could affect the amount of
calcium in one’s bones. The loss of calcium could lead to bone pain, bone fractures, and possibly even bone deformities. An x-ray
and blood test are needed to confirm this disorder.
2.
Which of the following statements is true concerning the extracellular matrix of bone?
a.
Osteoid is another name for the inorganic matrix and is composed of protein fibers and ground substance.
b.
Majority of the body’s calcium is stored within the inorganic matrix, in addition to other minerals such as phosphorus
and magnesium.
c.
The organic matrix is composed primarily of calcium and phosphorus salts that combine to form hydroxyapatite crystal.
d.
The strength of bone tissue is determined only by the inorganic matrix.
3.
The orthopedic physician discussed how the microscopic structure of CJ’s bones made them strong enough to support their
body weight and allows for movement
a.
Compare and contrast the histology of spongy and compact bone.
4.
Specifically focusing on the bones in CJ’s legs, describe the ossification process of these types of bones. How would the
ossification of the bones within the legs be different from the ossification of the skull bones?
5.
Previously stated, a concern of this disease is the effect it may have on bone growth.
a.
What are the five zones of the epiphyseal plate, starting from the epiphysis and ending at the diaphysis?
Name: _______________________________
b.
Describe the sequence of events that occur in the epiphyseal plate during the process of longitudinal bone growth.
The lab results came back indicating CJ’s renal function was abnormal. Specifically, their blood calcium ion levels were low and
parathyroid hormone levels were elevated. The lab results in addition to CJ’s signs and symptoms align with ROD.
6.
Low blood calcium ion levels are a significant sign of ROD.
a.
What is the negative feedback mechanism that occurs when the blood calcium ion level drops below the normal range?
b.
Chronic kidney disease disrupts the activity of vitamin D. How would you expect this to affect CJ’s blood calcium ion
level?
c.
What would you expect to happen to the PTH level in CJ’s blood if their blood calcium ion level was continuously
below normal?
7.
Following completion of the worksheet, please complete the corresponding quiz by November 3, 2023.
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