Nutrigenomics and Personalized Medicine
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Nov 24, 2024
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Nutrigenomics and Personalized Medicine
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Nutrigenomics and Personalized Medicine
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Loos, R. J. (2019). From nutrigenomics to personalizing diets: are we ready for precision medicine? The American Journal of Clinical Nutrition, 109(1), 1-2.
Dr. Ruth J.F. Loos is a prominent genetic epidemiologist specializing in the study of obesity and the Director of the Charles Bronfman Institute for Personalized Medicine's Genetics of Obesity and Related Metabolic Traits Program. In her research, she analyzed the state of nutrigenomics, the field that studies the link between diet and gene expression. Dr. Loos stated that while nutrigenomics is promising, it has yet to progress to the point where it can offer widely accepted personalized dietary recommendations. The obstacles stem from the intricate nature of diet-gene relationships, the effect of non-genetic factors, including lifestyle and gut microbes, and the need for more large-scale research. Therefore, until more definitive data is available, any claims of particular dietary recommendations based on nutrigenomics should be taken with caution.
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Singh, V. (2023). Current challenges and future implications of exploiting the ‘OMICS’ data into nutrigenetics and nutrigenomics for personalized diagnosis and nutrition-
based care. Nutrition, 112002.
In her study, Dr. Varsha Singh, an Assistant Professor of Medicine at Johns Hopkins University School of Medicine, discussed the possible implications of nutrigenomics in personalized medicine. She described how using OMICS data might lead to personalized dietary programs based on a person's unique genetic composition, greatly enhancing health outcomes. Additionally, Dr. Singh highlighted the potential transformative influence that nutrigenomics could exert on the healthcare system. She argued that it may reshape illness prevention and treatment practices by providing diet-based therapy alternatives suited to a person's genetic
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profile. The healthcare transformation could result in significant innovations in illness prevention, risk assessment, and treatment, opening up a new horizon in personalized medicine.
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Mishra, U. N., Jena, D., Sahu, C., Devi, R., Kumar, R., Jena, R., ... & Kumar, A. (2022). Nutrigenomics: an inimitable interaction amid genomics, nutrition and health. Innovative Food Science & Emerging Technologies, 82, 103196.
Dr. Udit Nandan Mishra is a renowned molecular biology and genomics scholar. He is an
Associate Professor in the Department of Molecular Biology at Sri Sri University in India. Mishra et al. elucidated the molecular mechanisms of nutrigenomics in their study published in Innovative Food Science & Emerging Technologies. The nutrients we eat can impact our genetic
expression, influencing cellular metabolism and general health— accomplished by modifying the
epigenome, a collection of chemical substances that tell the genome what to do. Some dietary constituents can act as substrates for enzymes that add or remove methyl groups, influencing gene expression. The study stresses the potential of nutrigenomics for recognizing people at risk of acquiring diet-related disorders, eventually leading to personalized nutrition recommendations.
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