Objectives1_AF

Chemistry Question

Please don't provide handwritten solution ....

Please don't provide handwritten solution ....

HCl(g) deltaG=-95.3O2(g) deltaG=0 H2O(g) deltaG=-228.6Cl2(g) deltaG=0

Consider a protein with five amino acids and three possible energy levels (separated by 1 J/mol) each amino acid can occupy. At what temperature will there be 45% of molecules in conformation A and 55% of molecules in conformation B? Comment on the size of this number and what distribution you would expect at room temperature. What does this mean about how "different" these energy levels are? Look back at the figure and propose an error made in reporting units. What energy unit would have likely been more appropriate in this case?

Past paper

Paroxetine (Paxil) is an antidepressant that is a member of a family of drugs known as Selective Serotonin Reuptake Inhibitors (SSRIS). This family of drugs also includes fluoxetine (Prozac) and sertraline (Zoloft). SSRIS work by inhibiting the reuptake of the neurotransmitter serotonin in the synapses of the central nervous system follow- ing release of serotonin during excitation of individual nerve cells. Between firings, the serotonin is taken back up by a nerve cell in preparation for firing again. Inhibition of reuptake has the effect of increasing the time serotonin molecules remain in the syn- apses following excitation, leading to a therapeutic effect. In one synthesis of parox- etine, the following reagents are used. Draw the structures of synthetic intermediates A and B. F НО SOCI, A B HO Pyridine

Explain the differences between molecular conjugation and bioconjugation for advanced drugdelivery. Please provide an example of each

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A cholesterol molecule consists of a polar region (shown in white) and a nonpolar region (shown in blue). The diagrams below show several possible orientations of a cholesterol molecule in a phospholipid micelle. Which seems most reasonable? Cholesterol

Hexadecyltrimethylammonium chloride, CH3(CH2)15N(CH3)+3 Cl-, is one of a class of cationic detergents, commonly used inshampoos and as “clothes rinses.”(a) Identify the hydrophilic head group and the hydrophobic tail.(b) Draw a depiction of a micelle that would form if this compound were dissolved in water.(c) What are the intermolecular forces that are primarily responsible for the micelle’s solubility in water?

I'm stuck on part  d, e, f, and g. Please help

1. Match three steroid structures shown below to the following values for Amax : Compound A, 275 nm; B, 304 nm, and C, 356 nm. CSH19 C9H19 C3H17 H3C° H3C HO

Gentiobose is found in saffron. Gentribose contains two glucose molecules linked by a beta (1 - 6) glycosidic bond. Describe how to draw the glycosidic linkage in this structure

Given the Ka values (in parentheses) for the following acids: HSO4– (Ka= 1.2 x 10–2); HNO2 (Ka= 4.0 x 10–4); HC2H3O2 (Ka= 1.8 x 10–5); Calculate Kc values for the following acid-base equilibria: (a) HSO4–(aq) + C2H3O2–(aq) ⇌ HC2H3O2(aq) + SO42–(aq) (b) HC2H3O2(aq) + NO2–(aq) ⇌ HNO2(aq)+ C2H3O2–(aq)

The mutated form of hemoglobin (hemoglobin S, or HbS) in sickle-cell anemia results from the replacement of a glutamate residue by a valine residue at position 6 in the ß chain of the protein. Normal hemoglobin is designated HbA. Under conditions of low [O₂], HbS aggregates and distorts the red blood cell into a sickle shape. See image of eight aggregated HbS molecules. Sickled red blood cells are relatively inflexible and may clog capillary beds, causing pain and tissue damage. The sickled red blood cells also have a shorter life span, leading to anemia. Which amino acids would be expected to produce a similar sickling effect if substituted for Val at position 6? arginine phenylalanine Aggregate of HbS molecules lysine leucine alanine Sickling occurs in deoxyhemoglobin S but not in oxyhemoglobin S. Oxyhemoglobin has a small, hydrophobic pocket in a B chain ranion located in the interior of the neotain In daaxshamaalahin homauar thic nookat is laastad on the curfona of tha 0

Given the following compounds and boiling points: Determine the IMFs Order the compounds from weakest to strongest IMFs, and Pentane (C5H12)                                     36°C Methane (CH4)                                     -164°C Sodium n-butoxide (C4H9NaO)      +260°C Hydrogen dioxide (H2O)                   100°C

Glycosaminoglycans (GAGs) are heteropolysaccharides composed of repeating disaccharide units. These units have some similar characteristics that allow them to be identified as GAGS. Which of the structures are examples of glycosaminoglycans? А. C. E. HO HO COO™ H Н ОН Н CH₂OH H H H OH OH Н CH₂OH Н OH H ОН o,so H H Н CH₂OH H H ОН H CH₂OSO H NH C=0 CH, H H Н NH c=0 CH3 H CH,OH OH Н ОН OH H B. D. Н НО H ОН H CH₂OH H ОН Н СОО ОН Н Н H H OSoz H Н OH б H CH₂OH ОН CH₂OSO H ОН H Н OSO, H Н NHSO,

The structure given below is a tetrasaccharide. i) For each pair of sugars (I-II, Il-III, III-IV), identify the type of linkage (i.e., 1→4, 1→6, etc.) that connects them. You do not have to specify whether the linkage is alpha or beta. ii) Identify all sugars that are in a furanose form. ОН ОН I HO- OH ОН О II Но OH Но НО HO- II ОН ОН IV

Which of the following antipsychotic agents presents the least EPS side effects? הפעל את עבור אל הגדר -01 OH