Which amino acids would be expected to produce a similar sickling effect if substituted for Val at position 6? arginine phenylalanine lysine leucine. alanine. Sickling occur in deoxyhemoglobin S but not in oxyhemoglobin S. Oxyhemoglobin has a small, hydrophobic pocket

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Chapter1: Chemical Foundations
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The mutated form of hemoglobin (hemoglobin S, or HbS) in sickle-cell anemia results from
the replacement of a glutamate residue by a valine residue at position 6 in the ß chain of the
protein. Normal hemoglobin is designated HbA.
Under conditions of low [O₂], HbS aggregates and distorts the red blood cell into a sickle
shape. See image of eight aggregated HbS molecules. Sickled red blood cells are relatively
inflexible and may clog capillary beds, causing pain and tissue damage. The sickled red
blood cells also have a shorter life span, leading to anemia.
Which amino acids would be expected to produce a similar sickling effect if substituted for Val at position 6?
arginine
phenylalanine
Aggregate of HbS molecules
lysine
leucine
alanine
Sickling occurs in deoxyhemoglobin S but not in oxyhemoglobin S. Oxyhemoglobin has a small, hydrophobic pocket in a B
chain ranion located in the interior of the neotain In daaxshamaalahin homauar thic nookat is laastad on the curfona of tha
0
Transcribed Image Text:The mutated form of hemoglobin (hemoglobin S, or HbS) in sickle-cell anemia results from the replacement of a glutamate residue by a valine residue at position 6 in the ß chain of the protein. Normal hemoglobin is designated HbA. Under conditions of low [O₂], HbS aggregates and distorts the red blood cell into a sickle shape. See image of eight aggregated HbS molecules. Sickled red blood cells are relatively inflexible and may clog capillary beds, causing pain and tissue damage. The sickled red blood cells also have a shorter life span, leading to anemia. Which amino acids would be expected to produce a similar sickling effect if substituted for Val at position 6? arginine phenylalanine Aggregate of HbS molecules lysine leucine alanine Sickling occurs in deoxyhemoglobin S but not in oxyhemoglobin S. Oxyhemoglobin has a small, hydrophobic pocket in a B chain ranion located in the interior of the neotain In daaxshamaalahin homauar thic nookat is laastad on the curfona of tha 0
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