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Kenyatta University School of Economics *

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2039

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Chemistry

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Nov 24, 2024

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docx

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3

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2 Online Class Activity Simple acid-base disturbance is a primary pathophysiologic process that is either acidosis or alkalosis and it is an appropriate compensatory mechanism. There are several things that take place in simple acid-base disturbance (Adrogué et al., 2009). First, there is a primary pathophysiologic process and then there is a compensatory mechanism. A combined acid-base disturbance on the other hand is a situation where one has more than one primary process taking place accompanied by several compensatory mechanisms. There are several examples of the simple acid-base disturbance. For instance, if a patient who has diabetic ketoacidosis stops using insulin will start breathing very fast. In this case, the person will have diabetic ketoacidosis and the compensatory respiratory alkalosis that accompanies it. On the other hand, combined acid-base disturbance will occur if the same patient stops taking the insulin, develops gastro-paresis that is very severe, and starts vomiting. The person will end up having diabetic ketoacidosis together with the kind of compensatory mechanism that it entails. In addition to this, the patient will have a metabolic alkalosis that comes from vomiting. The major difference between simple and combined acid-base disturbance is that the simple acid-base disturbance only involves the first or initial disturbance of the status of acid- base which is accompanied by the appropriate compensation level. Contrary, combined acid-base disturbance entails a concurrent manifestation of acid-base disturbance that occurs more than once. The only thing that helps in differentiating the two acid-base disturbances is their pH (Berend et al., 2014). For instance, the patient is always either acidemic or alkalinic. If the patient is acidemic then acidosis would be taking place and if the same patient is alkalinic then alkalosis would be automatically taking place.
3 References Adrogué, H. J., Gennari, F. J., Galla, J. H., & Madias, N. E. (2009). Assessing acid–base disorders. Kidney international , 76 (12), 1239-1247. Berend, K., de Vries, A. P., & Gans, R. O. (2014). Physiological approach to assessment of acid– base disturbances. New England Journal of Medicine , 371 (15), 1434-1445.
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