Discussion 5 (1)

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Name: _________________________ Biol-L311 Genetics Pre-lab questions – TO BE HANDED IN AT THE START OF DISCUSSION 5 1. For each of the following chromosome complements, what is the phenotypic sex of a person who has (3 marks) a. XY with the SRY gene deleted? b. XX with a copy of the SRY gene on an autosomal chromosome? c. XO with a copy of the SRY gene on an autosomal chromosome? d. XXY with the SRY gene deleted? e. XXYY with one copy of the SRY gene deleted? 2. Red–green color blindness in humans is due to an X-linked recessive gene. Both John and Cathy have normal color vision. After 10 years of marriage to John, Cathy gave birth to a color-blind daughter. John filed for divorce, claiming that he is not the father of the child. Is John justified in his claim of nonpaternity? Explain why. If Cathy had given birth to a color-blind son, would John be justified in claiming nonpaternity? (3 marks) Yes; the dads dominant X would allow the daughter to have normal vision. If the son was color blind, then he would not be justified. Kayleigh Goff female male male female male

3. Joe has classic hemophilia, an X-linked recessive disease. Could Joe have inherited the gene for this disease from the following persons? (2 marks) Yes No a. His mother’s mother __________ __________ b. His mother’s father __________ __________ c. His father’s mother __________ __________ d. His father’s father __________ __________ 4. In Drosophila , yellow body is due to an X-linked gene that is recessive to the gene for gray body. (4 marks) a. A homozygous gray female is crossed with a yellow male. The F 1 are intercrossed to produce F 2 . Give the genotypes and phenotypes, along with the expected proportions, of the F 1 and F 2 progeny. b. A yellow female is crossed with a gray male. The F 1 are intercrossed to produce the F2. Give the genotypes and phenotypes, along with the expected proportions, of the F 1 and F 2 progeny.

c. A yellow female is crossed with a gray male. The F 1 females are backcrossed with gray males. Give the genotypes and phenotypes, along with the expected proportions, of the F 2 progeny. d. If the F 2 flies in part b mate randomly, what are the expected phenotypic proportions of flies in the F 3 ? 5. Bob has XXY chromosomes (Klinefelter syndrome) and is color blind. His mother and father have normal color vision, but his maternal grandfather is color blind. Assume that Bob’s chromosome abnormality arose from nondisjunction in meiosis. In which parent and in which meiotic division did nondisjunction take place? Assume no crossing over has taken place. Explain your answer. (3 marks) Mother; sister chromatids would fail to separate in anaphase II. 1/8 X+Y 3/8 XyY 1/16 X+X+ 4/16 X+Xy 3/16 XyXy 1124 114 × -1 114 × 7 114 × +118 × +4 ' 116 × -1 × +1116 × +114 314 × 7318 XYY 3116 × +1143116 × 4 × 4

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