Micro Research

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1 Microbial Journal Article Review West Coast University - Miami MICR 290: Microbiology Professor Pedro Perez Diaz 5/22/22

2 Microbial Journal Article Review Question 1: Why did the scientists perform the study (i.e., description of background)? This review was conducted on the journal article, Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice, published by the journal Gut Microbes Volume 11 Issue 5. The scientists conducted this study because the microbe Akkermansia muciniphila is proving to have helpful effects on the metabolism, and discoveries have been made suggesting that this bacterium is a next generation beneficial microbe (Depommier et al., 2020, para. 4). As reported by Pitras (2021, paras. 3–4), anaerobic gram-negative Akkermansia muciniphila is a microbiota of the intestines colonized in the mucus layer of intestinal epithelial cells degrading mucus enzymes as its source of nutrients. Question 2: What was the hypothesis (or hypotheses) under investigation? The hypotheses of this study was that pasteurized Akkermansia muciniphila given daily would reduce diet induced obesity and would influence the use of energy and physical activity (Depommier et al., 2020, para. 5). The scientist noted that other studies have been done showing how having a large amount of Akkermansia muciniphila in the system shows a positive effect but no studies showed how pasteurized Akkermansia muciniphila can effect whole body metabolism and they wanted to prove the effects (Depommier et al., 2020, para. 5). Question 3: What were the major results and did they support or negate the hypothesis? Which key techniques were used to achieve these results? The researched conducted by Depommier et al. (2020, para.17), confirmed their body weight and fat, and increased physical activity. They also found through the feces a high

3 epithelial cell turnover, a decrease in absorption of certain carbohydrates and an increase in glucose tolerance (Depommier et al., 2020, para. 15-17). Materials and methods used by Depommier et al. (2020, para.18-21), were 8 week old male mice divided in three groups, one group receiving a normal diet, one group receiving an high fat diet, and one group receiving a high fat diet along with the pasteurized microbe Akkermansia muciniphila; they also used metabolic chambers to take measurements and they also took tissue, blood, and stool samples. Question 4: Why are the results significant and do they point to further/future studies? In other words, why does this article matter and what should or could be done next? These results are very significant in the study of weight management. The fact that a microbe that is a natural part of the microbiome of the human body can help reduce obesity and increase energy is a positive factor for treatments of weight control that is natural. Studies should continue to be done with A muciniphila the help combat the weight epidemic in our society. There are many diseases contributed to obesity and if this microbe can help prevent these adverse issues it should be studied thoroughly. Question 5: Why did you choose this particular article to review? Was it interesting, informative, clearly written, or none of the above? I choose this article because strategies to lose weight is a prevalent topic. Many people look for ways to fight obesity or weight gain that can be in addition to diet and exercise. It was very interesting to learn about a microbe that is beneficial in assisting in weight management and energy production. The article was very informative to the recent studies that have been conducted with Akkermansia muciniphila and its success in the areas of obesity. It was clearly written and a joy to read.

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4 References Depommier, C., van Hul, M., Everard, A., Delzenne, N. M., de Vos, W. M., & Cani, P. D. (2020). Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice. Gut Microbes , 11 (5), 1231–1245. https://doi.org/10.1080/19490976.2020.1737307 Pitras, J. (2021, March 29). What is Akkermansia muciniphila? A-Mansia Biotech. https://www.a-mansia.com/what-is-akkermansia-muciniphila/

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