Quiz_ Cancer Pharmacology_ MSCI500_ Foundations of Biomedical Sciences (D01)

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2/18/24, 12:55 AM Quiz: Cancer Pharmacology: MSCI500: Foundations of Biomedical Sciences (D01) https://canvas.liberty.edu/courses/530129/quizzes/2631278 1/7 Quiz: Cancer Pharmacology Due Dec 10, 2023 at 11:59pm Points 40 Questions 23 Time Limit 46 Minutes This quiz is no longer available as the course has been concluded. Attempt History Attempt Time Score LATEST Attempt 1 15 minutes 39 out of 40  Correct answers are hidden. Score for this quiz: 39 out of 40 Submitted Dec 9, 2023 at 10:36pm This attempt took 15 minutes.  Question 1 1.75 / 1.75 pts L-Asparaginase Pentostatin Methotrexate 5-Fluorouracil  Question 2 1.75 / 1.75 pts Topotecan Doxorubicin Etoposide Mitoxantrone  These anticancer drugs work by inhibiting DNA synthesis except; These are topoisomerase II inhibitors except; Online Residential Athletics Sign In Request Info Apply Now Visit Us Create Guest Account

2/18/24, 12:55 AM Quiz: Cancer Pharmacology: MSCI500: Foundations of Biomedical Sciences (D01) https://canvas.liberty.edu/courses/530129/quizzes/2631278 2/7 Question 3 1.75 / 1.75 pts Bortezomib Actinomycin-D Cyclophosphamide Busulfan  Question 4 1.75 / 1.75 pts Selectivity Therapeutic index Dose of toxicity Potency  Question 5 1.75 / 1.75 pts Log phase Therapeutic window Selectivity Targeted therapeutics  Question 6 1.75 / 1.75 pts Letrozole Paclitaxel Methotrexate Megestrol  Which of these cancer chemotherapeutic agents works by inhibiting protein degradation The ratio of LD50 to ED50 of a drug is described as its; The reciprocal of the concentration of a drug required to inhibit 50% of its target's activity when all possible ligand and substrate concentrations have been controlled for is called; In a breast cancer patient whose tumor cells express large amounts of estrogen receptors and are therefore very sensitive to estradiol, which of these drugs will be very effective in reducing plasma levels of estradiol and consequently the breast tumor growth?

2/18/24, 12:55 AM Quiz: Cancer Pharmacology: MSCI500: Foundations of Biomedical Sciences (D01) https://canvas.liberty.edu/courses/530129/quizzes/2631278 3/7 Question 7 1 / 1 pts Tamoxifen Raloxifene Fulvestrant Bexarotene  Question 8 1 / 1 pts Imatinib Traztuzumab Zaltrap Bevacizumab  Question 9 1 / 1 pts Increased DNA repair capacity Expression of drug e©ux pumps Overexpression of hedgehog and notch signaling pathways All of these  Question 10 1.75 / 1.75 pts Methotrexate 5-§urouracil Pemetrexed In a 55 year old female breast cancer patient whose tumor cells are estrogen sensitive, which of the following chemotherapeutic agents is most likely to control the breast tumor growth but predispose the patient to endometrial cancer? Which of these agents targets the tyrosine kinase domain of the fusion protein formed from the Philadelphia chromosome and will be helpful in chronic myelogenous leukemia? Which of these describes a mechanism of chemoresistance exhibited by skin and colon stem cells? This drug exerts its anticancer effects by inhibiting the enzyme - dihydrofolate reductase thereby depleting the cellular folate pool and inhibiting de novo purine synthesis;

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2/18/24, 12:55 AM Quiz: Cancer Pharmacology: MSCI500: Foundations of Biomedical Sciences (D01) https://canvas.liberty.edu/courses/530129/quizzes/2631278 4/7 5'deoxy-5'-§urouridine  Question 11 1.75 / 1.75 pts Irinotecan Methotrexate Gemcitabine Cyclophosphamide  Question 12 1.75 / 1.75 pts RNA polymerase DNA polymerase Ribonucleotide reductase Topoisomerase II  Question 13 3 / 3 pts Irinotecan Chinese Yew Tree Paclitaxel Paci¦c Yew Tree (Bark) Vinblastine Pink Periwinkle  This drug is a front-line drug in inoperable, locally-advanced or recurrent non-small cell lung cancer and works by forming active diphosphates that inhibit DNA polymerase and ribonucleotide reductase; This therapeutic target is involved in DNA repair and works by inserting double-stranded breaks in DNA; Match these chemotherapeutic agents to their plant sources;

2/18/24, 12:55 AM Quiz: Cancer Pharmacology: MSCI500: Foundations of Biomedical Sciences (D01) https://canvas.liberty.edu/courses/530129/quizzes/2631278 5/7 Question 14 4 / 4 pts Goserelin Gonadotropin receptor Pentostatin Adenosine deaminase Cetuximab EGFR L-Asparaginase Protein synthesis inhibitor  Question 15 1.75 / 1.75 pts True False  Question 16 1.75 / 1.75 pts IgA IgE IgG IgM  Match these drugs to their molecular targets and mechanisms of action; You are evaluating apatient with a cancer type that is characterized by constitutive expression of NF Ϗ B - which promotes oncogenesis, Bortezomib will be most effective in managing the patient. The most commonly used Ig isotype used in cancer immunotherapy is;

2/18/24, 12:55 AM Quiz: Cancer Pharmacology: MSCI500: Foundations of Biomedical Sciences (D01) https://canvas.liberty.edu/courses/530129/quizzes/2631278 6/7 Question 17 1.75 / 1.75 pts Constant region Fragment of crystallization Fragment of antigen binding Compliment determining region  Question 18 1.75 / 1.75 pts CD86 CD64 CD32A CD16  Question 19 1.75 / 1.75 pts True False  Question 20 1.75 / 1.75 pts Pantimumab Traztuzumab Rituximab Oregovomab The functional modality of an antibody that is composed of V + C V + C L L and H H1 is the; Whichof these is not an activating FC γ R expressed in hematopoietic cells in humans used for inducing antibody-dependent cell-mediated cytotoxicity? Herceptin is an anti-HER2/neu monoclonal antibody that works by directly inhibiting ligand binding to EFGR2. Which of these immunotherapeutic agents is a human monoclonal antibody?

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2/18/24, 12:55 AM Quiz: Cancer Pharmacology: MSCI500: Foundations of Biomedical Sciences (D01) https://canvas.liberty.edu/courses/530129/quizzes/2631278 7/7  Question 21 1.75 / 1.75 pts The y link the variable region of an anti-tumor antibody with the variable region of an anti-CD3 antibody They induce a robust polyclonal B-cell activation They can induce tumor cell lysis They can stimulate T-cells without stimulatory signals and MHC expression  Question 22 1 / 1 pts Fucose Glucose Mannose Galactose  IncorrectQuestion 23 0 / 1 pts CD27 CD28 TIM3 CD40L Quiz Score: 39 out of 40 Which of these is not true about Bispeci¦c T-cell Engagers? The removal of this sugar residue from human IgG monoclonal antibodies enhances their capacity to mediate antibody-dependent cell-mediated cytotoxicity? A drug that inhibits the expression of this molecule on the surface of T cells will potentiate the activation of T cells and exert antitumor effects;

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