ANATOMY PHYS VOL II W ACCESS CUSTOM
9th Edition
ISBN: 9781264412303
Author: SALADIN
Publisher: MCG CUSTOM
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Chapter A, Problem 10TYR
Summary Introduction
Introduction:
In order to live, the whole body system needs to co-operate with each other. To achieve this, there are different body systems that carry out specific functions but co-operate with each other to maintain life.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter A Solutions
ANATOMY PHYS VOL II W ACCESS CUSTOM
Ch. A.1 - Anatomical position and why it is important for...Ch. A.1 - Directions along which the body or an organ is...Ch. A.1 - Meanings of each of the following pairs or groups...Ch. A.1 - Why the terms ventral and dorsal are ambiguous in...Ch. A.2 - Distinctions between the axial and appendicular...Ch. A.2 - Prob. 2AYLOCh. A.2 - Prob. 3AYLOCh. A.2 - Prob. 4AYLOCh. A.3 - locations and contents of the cranial cavity;...Ch. A.3 - Prob. 2AYLO
Ch. A.3 - Prob. 3AYLOCh. A.3 - The pleurae, their two layers, the space and fluid...Ch. A.3 - The two subdivisions of the abdominopelvic cavity...Ch. A.3 - Prob. 6AYLOCh. A.3 - Mesenteries and serosaeCh. A.3 - Prob. 8AYLOCh. A.3 - Prob. 9AYLOCh. A.3 - Prob. 10AYLOCh. A.3 - Examples of potential spaces and why they are so...Ch. A.4 - The 11 organ systems, the functions of each, and...Ch. A - Which of the following is not an essential part of...Ch. A - A ring-shaped section of the small intestine would...Ch. A - Prob. 3TYRCh. A - The greater omentum is _______ to the small...Ch. A - A ______ plane passes through the sternum,...Ch. A - Prob. 6TYRCh. A - Prob. 7TYRCh. A - Prob. 8TYRCh. A - Prob. 9TYRCh. A - Prob. 10TYRCh. A - The translucent membranes that suspend the...Ch. A - Prob. 12TYRCh. A - Prob. 13TYRCh. A - Prob. 14TYRCh. A - The manual region is more commonly known as the...Ch. A - Prob. 16TYRCh. A - Prob. 17TYRCh. A - Prob. 18TYRCh. A - Prob. 19TYRCh. A - Prob. 20TYRCh. A - Prob. 1BYMVCh. A - Prob. 2BYMVCh. A - Prob. 3BYMVCh. A - Prob. 4BYMVCh. A - inguino-Ch. A - Prob. 6BYMVCh. A - Prob. 7BYMVCh. A - Prob. 8BYMVCh. A - Prob. 9BYMVCh. A - Prob. 10BYMVCh. A - Prob. 1WWTSCh. A - Prob. 2WWTSCh. A - Prob. 3WWTSCh. A - Prob. 4WWTSCh. A - Prob. 5WWTSCh. A - Prob. 6WWTSCh. A - Prob. 7WWTSCh. A - Prob. 8WWTSCh. A - Prob. 9WWTSCh. A - Prob. 10WWTSCh. A - Prob. 1TYCCh. A - Prob. 2TYCCh. A - Name one structure or anatomical feature that...Ch. A - Prob. 4TYCCh. A - Prob. 5TYC
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