EP PRINCIPLES OF HUM.PHYS.-MOD.MAST.A+P
6th Edition
ISBN: 9780134407166
Author: STANFIELD
Publisher: PEARSON CO
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Textbook Question
Chapter 9.4, Problem 9.4.1QC
Is salivation in response to a bell an example of an innate reflex or a conditioned reflex? Why? What about salivation in response to the smell of food?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 9 Solutions
EP PRINCIPLES OF HUM.PHYS.-MOD.MAST.A+P
Ch. 9.1 - Describe the symptoms and causes of multiple...Ch. 9.1 - What are the main areas of commonality between...Ch. 9.1 - What are the key differences between these three...Ch. 9.1 - Prob. 1aCTQCh. 9.1 - Prob. 2aCTQCh. 9.1 - Identify differences in the treatment and expected...Ch. 9.1 - Prob. 9.1.1QCCh. 9.1 - Prob. 9.1.2QCCh. 9.1 - Prob. 9.1.3QCCh. 9.2 - Prob. 9.2.1QC
Ch. 9.2 - Prob. 9.2.2QCCh. 9.2 - Prob. 9.2.3QCCh. 9.3 - Prob. 9.3.1QCCh. 9.3 - Prob. 9.3.2QCCh. 9.3 - Prob. 9.3.3QCCh. 9.3 - For each of the following functions, indicate...Ch. 9.4 - Is salivation in response to a bell an example of...Ch. 9.4 - Prob. 9.4.2QCCh. 9.5 - Prob. 9.5.1QCCh. 9.5 - Prob. 9.5.2QCCh. 9.7 - Describe how cortisol and the autonomic nervous...Ch. 9.7 - Prob. 2CTQCh. 9.7 - What do you suppose are the limitations of current...Ch. 9.7 - Prob. 9.6.1QCCh. 9.7 -
Which types of EEG changes are observed as a...Ch. 9.7 - What is the ascending reticular activating system,...Ch. 9.9 - Prob. 9.7.1QCCh. 9.9 - Prob. 9.7.2QCCh. 9 - Prob. 1ECh. 9 - Prob. 2ECh. 9 - Prob. 3ECh. 9 - Prob. 4ECh. 9 - Prob. 5ECh. 9 -
The origin of neurons of the corticospinal tract...Ch. 9 -
Which of the following is not a component of the...Ch. 9 - Prob. 8ECh. 9 - Prob. 9ECh. 9 - Prob. 10ECh. 9 - Prob. 11ECh. 9 - Prob. 12ECh. 9 - Prob. 13ECh. 9 - Prob. 14ECh. 9 - Prob. 15ECh. 9 - Prob. 16ECh. 9 - Prob. 17ECh. 9 - Prob. 18ECh. 9 - Prob. 19ECh. 9 - Prob. 20ECh. 9 - Prob. 21ECh. 9 - Prob. 22ECh. 9 - Prob. 23ECh. 9 - Prob. 24ECh. 9 - Prob. 25ECh. 9 -
Describe the different structures that protect...Ch. 9 -
Describe the energy supply to the brain.
Ch. 9 - Prob. 28ECh. 9 - Prob. 29ECh. 9 - Prob. 30ECh. 9 -
Describe the roles of NMDA and AMPA receptors in...Ch. 9 - Prob. 32ECh. 9 -
Suppose a person suffers a stroke that affects...Ch. 9 -
Reflexes can be overridden by voluntary controls....Ch. 9 -
Paralysis refers to the inability to voluntarily...
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