Videos
Children with Muscular Disorders
You're doing a clinical rotation with Dr. Barr, a world-renowned specialist in children's muscle disorders. On your first day, you meet three patients with the same probable diagnosis—nemaline myopathy. Jodi, age 2, has a waddling walk and difficulty standing; Linda. 6 months, has pneumonia associated with problems swallowing; and Tom, 12, has progressive weakness with foot drop and difficulty walking.
“This kind of variation is not surprising.” says Dr. Barr. “A mutation in one of 11 different genes related to thin filaments can cause nemaline myopathy, so you’d expect to see it present in different ways.”
Dr. Barr has scheduled all three children for a muscle biopsy (surgical removal of a small piece of muscle tissue for examination). He explains to you. “We’re going to use these biopsies for two things. First, we're going to look for the characteristic histology of nemaline myopathy. Second, we're going to test for malignant hyperthermia. It's not associated with nemaline myopathy but is associated with a different myopathy that has a similar presentation.”
Malignant hyperthermia is caused by a mutation in a gene related to calcium storage and release in skeletal muscle cells. In individuals with malignant hyperthermia, certain anesthetics can trigger a massive release of calcium into the cytoplasm. This leads to the generation of enough heat to substantially raise body temperature—a life-threatening reaction.
4. + NCLEX-STYLE Which statement best describes the importance of calcium in skeletal muscle contraction?
a. Extracellular calcium entering through ion channels binds to troponin to initiate muscle contraction.
b. Extracellular calcium entering through ion channels binds to tropomyosin to initiate muscle contraction.
c. Calcium released from the sarcoplasmic reticulum binds to tropomyosin to initiate muscle contraction.
d. Calcium released from the sarcoplasmic reticulum binds to troponin to initiate muscle contraction.
Want to see the full answer?
Check out a sample textbook solution
Chapter 9 Solutions
HUMAN A&P E-TEXT ACCESS CODE
- Identify the indicated structure (Saprolegnia). a. antheridium O b. oospore c.sperm d. auxospore e. tetraspore Of. zygosporearrow_forwardUsing information from the primary literature (several references have been provided as a starting point below) please answer the following question: Based on your review of the literature on rewilding, what are the major scientific pros and cons for rewilding? Please note that the focus of this assignment are the (biological) scientific issues associated with rewilding. As will be discussed in class, there are a number of non-scientific issues involved or implicated in rewilding, all ultimately affecting the public acceptability of rewilding. Although these issues are important – indeed, critical – in this assignment you should focus on the biological science issues and questions. Details: You must enumerate at least two pros and at least two cons. Your answer should be no more than 500 well-chosen words, excluding references. Think carefully about how best to organize and structure your answer. Aim for high information density: say a lot, but say it succinctly. Recall Nietzche’s…arrow_forwardUsing information from the primary literature (several references have been provided as a starting point below) please answer the following question: Based on your review of the literature on rewilding, what are the major scientific pros and cons for rewilding? Please note that the focus of this assignment are the (biological) scientific issues associated with rewilding. As will be discussed in class, there are a number of non-scientific issues involved or implicated in rewilding, all ultimately affecting the public acceptability of rewilding. Although these issues are important – indeed, critical – in this assignment you should focus on the biological science issues and questions. Details: You must enumerate at least two pros and at least two cons. Your answer should be no more than 500 well-chosen words, excluding references. Think carefully about how best to organize and structure your answer. Aim for high information density: say a lot, but say it succinctly. Recall Nietzche’s…arrow_forward
- Now draw a rough sketch of what the control data might look like if in addition to the specific binding, there was also a considerable amount of nonspecific binding (again using a normal dose/response curve) (do % total bound ligand vs concentration)arrow_forwardWhat are functions of cuboidal cells in the kidney? Select all that apply. Concentration of gases Dilution of chemicals Secretion of molecules Nutrition to tissues Support of tissues Absorption of moleculesarrow_forwardquestion1 In plants, epithelial tissue is only found as the outermost cell layer and acts as a barrier. In humans, epithelial tissue is found inside the body as well as on the surface. What function(s) does/do epithelial tissue carry out in humans? Select all that apply. Waste storage Filtration Oxygen transport Protection Diffusion Osmosis Absorptionarrow_forward
- What words best describes this organism? a. Unicellular/nonmotile Ob. unicellular/motile c. colonial/nonmotile d. colonial/motile e. multicelluar O f. siphonous g. none of thesearrow_forwardIdentify the phylum or class. a. Euglenophyta b. Dinoflagellata c. Bacillariophyceae d. Oomycetes e. Phaeophyceae O f. Myxomycota g. Xanthophyceae ○ h. Chrysophyceae i. Dictyosteliomycota O j. Rhodophyta Ok. Chlorophyceaens I. Charophyceaensarrow_forwardWhat is produced inside the indicated structure (Fucus). a. eggs O b. antheridia ○ c. sperm d. zygotes e. none of thesearrow_forward
Medical Terminology for Health Professions, Spira...Health & NutritionISBN:9781305634350Author:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. SchroederPublisher:Cengage Learning
Comprehensive Medical Assisting: Administrative a...NursingISBN:9781305964792Author:Wilburta Q. Lindh, Carol D. Tamparo, Barbara M. Dahl, Julie Morris, Cindy CorreaPublisher:Cengage Learning
Lifetime Physical Fitness & WellnessHealth & NutritionISBN:9781337677509Author:HOEGERPublisher:Cengage
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning