HUMAN BIOLOGY:CONC.+CURRENT..(LOOSE)
HUMAN BIOLOGY:CONC.+CURRENT..(LOOSE)
7th Edition
ISBN: 9780321862525
Author: Johnson
Publisher: PEARSON
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Chapter 9, Problem 3TY
Summary Introduction

Introduction:

There are some agents which can lead to misfolding of proteins. The misfolding can cause severe dysfunctions in the cells they enter. However, what makes these proteins dangerous is that, not only are they themselves misfolded, they can also lead to misfolding of proteins around them. This is the primary mechanism behind the neurodegenerative diseases caused by these proteins.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
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