Biology
12th Edition
ISBN: 9780078024269
Author: Sylvia Mader, Michael Windelspecht
Publisher: McGraw-Hill Education
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Chapter 9, Problem 3TS
BPA is a chemical compound that has historically been used in manufacture of plastic products. However, cells often mistake BPA compounds for that accelerate the cell cycle. Because of this, BPA is associated with an increased riskof certain cancers.
a. How might BPA interact with the cell cycle and its checkpoints?
b. Why do you think that very small concentrations of BPA might have a large effect on cell?
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BPA is a chemical compound that has historically been used in themanufacture of plastic products. However, cells often mistake BPAcompounds for hormones that accelerate the cell cycle. Because ofthis, BPA is associated with an increased risk of certain cancers.
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Chapter 9 Solutions
Biology
Ch. 9.1 - 1. List, in order, the stages of the cell cycle...Ch. 9.1 - 2. Explain what conditions might cause a cell to...Ch. 9.1 - Discuss how apoptosis represents a regulatory...Ch. 9.2 - Prob. 1CYPCh. 9.2 - List the stages of chromosome compacting, starting...Ch. 9.3 - Prob. 1CYPCh. 9.3 - Prob. 2CYPCh. 9.3 - Discuss the importance of stem cells in the human...Ch. 9.4 - Prob. 1CYPCh. 9.4 - Prob. 2CYP
Ch. 9.4 - Prob. 3CYPCh. 9.5 - Prob. 1CYPCh. 9.5 - Prob. 2CYPCh. 9 - 1. What is the potential effect of abnormally high...Ch. 9 - 2. Why might some cancers be associated with a...Ch. 9 - Prob. 2NS.1QCCh. 9 - Prob. 2NS.2QCCh. 9 - Prob. 1ACh. 9 - Prob. 2ACh. 9 - Prob. 3ACh. 9 - Prob. 4ACh. 9 - Prob. 5ACh. 9 - Prob. 6ACh. 9 - Prob. 7ACh. 9 - Prob. 8ACh. 9 - Prob. 9ACh. 9 - Prob. 10ACh. 9 - Prob. 11ACh. 9 - Prob. 12ACh. 9 - Prob. 13ACh. 9 - Prob. 14ACh. 9 - Prob. 15ACh. 9 - Prob. 1TSCh. 9 - 2. The survivors of atomic bombs that were dropped...Ch. 9 - BPA is a chemical compound that has historically...Ch. 9 - Prob. 4TS
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- Which of the following statements is a lie?Select one: a. If damaged DNA is detected during the cell cycle, negative regulation is responsible in stopping the cell cycle. b. There are four cyclin proteins involved in the positive regulation of the cell cycle and they have fluctuating levels. c. To activate cyclin-dependent kinases (Cdks), they must bind to another kinase.arrow_forwardIn the following study, the investigators wanted to determine the role of cyclin B in controlling the cell cycle. Earlier researchers had found that extracts made from frog eggs (Xenopus) contained all the necessary proteins and machinery required for DNA replication. This included proteins that regulated the mitosis promoting factor (MPF). At the time of this study, cyclin B was show to affect MPF activity and the research group wanted to test using Xenopus egg extract in an assay. In Figure 1 (a) MPF activity was tested for its ability to phosphorylate Histone (H1) in sperm chromatin over a certain period of time. Additionally, the cyclin B concentration in the extract was measured. In figure 1b, the extract was tested after treatment with RNase which degraded only the mRNA and not RNA or FRNA in the extract. Knowing that cyclin B is a short-lived protein, why do you suppose the graph shows the results you see in figure 1b?arrow_forwardChemotherapy utilizes chemicals to interrupt various parts of the cell cycle, targeting rapidly growing cells. Taxol® is an example of a drug that prevents mitosis phase from occurring. How this Taxol useful as a cancer treatment and how might targeting rapidly growing cells explain common chemotherapy side effects such as hair loss and nausea? A. Taxol will stop the tumor from growing, but unfortunately it also impacts other fast-growing cells (like hair follicles and stomach lining cells), so normal cells get damaged as well. B. Taxol will stop the tumor from continuing to divide, but unfortunately it also impacts other readily dividing cells (like hair follicles and stomach lining cells), so normal cells get damaged as well. C. Taxol will stop the tumor from copying DNA, but unfortunately it also impacts DNA replication in other cells (like hair follicles and stomach lining cells), so normal cells don't get to continue through…arrow_forward
- (46) A mutated form of protein p5x is found in patients with squamous cell carcinoma. In vitro studies show that the normal p5x molecule binds to DNA, and neoplastic cells accumulate in the G0 phase of the cell cycle. In contrast, the mutated form of p5x does not bin d to DNA. These finding are most characteristics of which of the following? (A) Growht factor receptors (B) GTP-binding protein (C) Nonreceptor tyrosine kinases (D) Oncogene proteins (E) Tumor suppressor gene proteinsarrow_forward(a) the cell cycle is divided into different phases (referred to as M, G0, G1, S and G2); Can you account for what happens during the different parts of the cycle and out of it is checked? ( b) What is the difference between apoptosis and necrosis? ( c) What are caspases and what is their function in the cell?arrow_forwardDescribe the likely consequences of bypassing the G1 and G2 checkpoints in the cell cycle. Why do compounds like nonylphenol lead to the multiplication of abnormal cells?arrow_forward
- Sometimes a cells "deal with" damaged DNA by just killing off the cell. This special cellular suicide is called apoptosis. Usually, the cell cycle has checkpoints that prevent damaged/mutated cells from proceeding to the next phase, though. When these checkpoints don't work, apoptosis can be used. If apoptosis did NOT occur, how might the damaged DNA impact the rest of the cell cycle? A. it may not complete the cell cycle correctly B. new cells containing damaged DNA may be made C. the cell may enter G0 D. all of the above are options E. A and B, but not C F. B and C, but not Aarrow_forwardOverexpression of the Myc protein is a common feature of many types of cancer cells, contributing to their excessive cell growth and proliferation. By contrast, when Myc is overexpressed in most normal cells, the result is not excessive proliferation, but cell-cycle arrest or apoptosis.Which one of the following statements provides the most likely explanation for why overexpression of Myc can have such different outcomes in normal cells and in cancer cells? A. Normal cells contain checks and balances that prevent Myc-induced proliferation. B. In normal cells, Myc protein acts as a mediator in cell-cycle arrest and apoptosis. C. The target protein for Myc-induced proliferation is missing from most normal cells. D. In normal cells, when Myc is overexpressed, the excess Myc protein precipitates.arrow_forwardA cell inherits a mutation in a gene that results in a transcription factor, called NF-kB, constantly being in its active conformation. When active, NF-kB stimulates the expression of cyclins that promote progression of the cell cycle, regardless of other conditions. As a result of this mutation, how would this cell's phenotype be affected by this mutation? A) This cell would have a cancer phenotype B) This cell would grow larger in size, but would never divide C) This cell would likely undergo apoptosis D) This cell would not duplicate its chromosomes .arrow_forward
- Cell division cycle mutations render the mutants unable to continue the cell cycle. This phenotype creates a paradox where mutant cells must also be grown in the lab to further identify the gene and study the role of the protein. How do you think this problem can be solved?arrow_forward(46) A mutated form of protein pox is found in patients with squamous cell carcinoma. In vitro studies show that the normal p5x molecule binds to DNA, and neoplastic cells accumulate in the G0 phase of the cell cycle. In contrast, the mutated form of p5x does not bind to DNA. These finding are most characteristics of which of the following? (A) Growht factor receptors (B) GTP-binding protein (C) Nonreceptor tyrosine kinases (D) Oncogene proteins (E) Tumor suppressor gene proteinsarrow_forwardHow does the dysregulation of cell cycle checkpoints contribute to the development of cancer?arrow_forward
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cell division of meiosis and mitosis; Author: Stated Clearly;https://www.youtube.com/watch?v=A-mFPZLLbHI;License: Standard youtube license