RESEARCH METHODS-W/ACCESS >CUSTOM<
5th Edition
ISBN: 9781305743625
Author: GRAVETTER
Publisher: CENGAGE C
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Chapter 9, Problem 3E
Briefly explain how an order effect such as fatigue can be a confounding variable in a within-subjects design.
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In a crossover trial comparing a new drug to a standard, π denotes the probabilitythat the new one is judged better. It is desired to estimate π and test H0 : π = 0.5against H1 : π = 0.5. In 20 independent observations, the new drug is better eachtime.(a) Find and plot the likelihood function. Give the ML estimate of π (Hint: youmay use the plot function in R)
Can you explain what this analysis means in layman's terms?
- We calculated that a target sample size of 3626, which was based on anticipated baseline 90-day mortality of 22% and a noninferiority margin of no more than 4 percentage points, would give the trial 80% power, at a one-sided alpha level of 2.5%, accounting for a maximum of 5% loss to follow-up and for early stopping rules for three interim analyses.-
Can you help me understand this analysis?
A 95.7% confidence interval is shown for the intention-to-treat analysis (accounting for alpha spending in interim analyses), and 95% confidence intervals are shown for the other two analyses. The widths of the confidence intervals have not been adjusted for multiplicity. The dashed line indicates the noninferiority margin of 4 percentage points.
Chapter 9 Solutions
RESEARCH METHODS-W/ACCESS >CUSTOM<
Ch. 9.1 - Describe the general characteristics of a...Ch. 9.1 - Describe how time-related factors such as history,...Ch. 9.2 - For a within-subjects experiment, explain how the...Ch. 9.2 - Define counterbalancing and explain how it is used...Ch. 9.2 - Describe the limitations of counterbalancing and...Ch. 9.3 - Explain the general advantages and disadvantages...Ch. 9.3 - Define a matched-subject design and explain how it...Ch. 9.4 - Describe the different ways that within-subjects...Ch. 9 - In addition to the key words, you should also be...Ch. 9 - Describe the characteristics of a within-subjects...
Ch. 9 - Briefly explain how an order effect such as...Ch. 9 - Under what circumstances is it advisable to switch...Ch. 9 - Describe the process of counterbalancing and the...Ch. 9 - Describe the circumstances in which...Ch. 9 - What is the advantage of removing the variability...Ch. 9 - Explain how a within-subjects design avoids the...Ch. 9 - A researcher has a sample of 30 rats that are all...Ch. 9 - Explain how a matched-subjects design attempts to...Ch. 9 - Describe the disadvantages of a multiple-treatment...Ch. 9 - researcher has a sample of 30 rats that are all...Ch. 9 - In a Latin square, each treatment condition occurs...
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