Pearson eText Human Anatomy -- Instant Access (Pearson+)
9th Edition
ISBN: 9780135212936
Author: Frederic Martini, Robert Tallitsch
Publisher: PEARSON+
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Textbook Question
Chapter 9, Problem 1RFT
Active sites on actin become available for binding when
(a) calcium binds to troponin.
(b) troponin binds to tropomyosin.
(c) calcium binds to tropomyosin.
(d) actin binds to troponin.
Expert Solution & Answer
Summary Introduction
Introduction:
Muscles are made up of two main protein filaments namely, a thick filament that is made up of a protein called myosin and a thin filament that is composed of a protein known as actin. When these two filaments crossover one another in a row of repetitive events then muscle contraction takes place.
Answer to Problem 1RFT
Correct answer:
Thin filament consists of regulatory proteins called tropomyosin and troponin and the calcium ions binds with the troponin.
Explanation of Solution
Explanation for the correct answer:
Option (a) is given as calcium binds to troponin. The muscle contraction takes place in a series of steps. The cycle starts with electrical events in the sarcolemma. This accelerates the generation of calcium ions from the cisternae of the sarcoplasmic reticulum. The calcium ions then enter the zone of overlap. The next step involves binding of these calcium ions to troponin in the complex of troponin-tropomyosin. This alters the position and rolls the tropomyosin molecule away from the active sites present on the actin. This makes the active sites exposed for the formation of cross-bridges. Hence option (a) is correct.
Explanation for the incorrect answers:
Option (b) is given as troponin binds to tropomyosin. Troponin binds to the troponin-tropomyosin complex and rolls away from the tropomyosin complex. So, it is a wrong answer.
Option (c) is given as calcium binds to tropomyosin. Calcium binds to the troponin molecule instead of tropomyosin molecule. So, it is a wrong answer.
Option (d) is given as actin binds to troponin. Troponin binds to the calcium and makes actin sites exposed. So, it is a wrong answer.
Hence, option (b), (c) and (d) are incorrect.
Conclusion
Therefore, it can be concluded that calcium ions bind to the troponin and this troponin then binds to the troponin-tropomyosin complex, making active sites exposed during muscle contractions.
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Chapter 9 Solutions
Pearson eText Human Anatomy -- Instant Access (Pearson+)
Ch. 9 - 1. Active sites on actin become available for...Ch. 9 - Prob. 2RFTCh. 9 - Prob. 3RFTCh. 9 - 4. Another name for a muscle that is a prime mover...Ch. 9 - Prob. 5RFTCh. 9 - Prob. 6RFTCh. 9 - 7. The theory that explains muscle contraction is...Ch. 9 - Prob. 8RFTCh. 9 - Label the illustrations to the right as...Ch. 9 - Prob. 1RC
Ch. 9 - 2. The ability to recover from injuries in older...Ch. 9 - Prob. 3RCCh. 9 - Prob. 4RCCh. 9 - Prob. 5RCCh. 9 - A motor unit from a skeletal muscle contains 1500...Ch. 9 - 7. What is the role of the zone of overlap in...Ch. 9 - Several anatomy students take up weight lifting...Ch. 9 - Prob. 2CT
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