BIOCHEMISTRY
BIOCHEMISTRY
8th Edition
ISBN: 9781319296186
Author: BERG
Publisher: MAC HIGHER
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Chapter 9, Problem 14P
Interpretation Introduction

Interpretation:

The reason for the incorporation of O18 in the ATP molecule should be determined.

Concept Introduction:

ATP (adenosine monophosphate) is an organic molecule and the chemical that provides energy to the cell. Muscular contractions, chemical synthesis, and nerve impulse propagation, all these activities are run by ATP derived energy. It is synthesized in the mitochondria; therefore, mitochondria are termed as the powerhouse of the cell.

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Please draw out the mechanism with curved arrows showing electron flow. Pyruvate is accepted into the TCA cycle by a “feeder” reaction using the pyruvate dehydrogenase complex, resulting in acetyl-CoA and CO2. Provide the mechanism for this reaction utilizing the TPP cofactor. Include the roles of all cofactors.
Pyruvate is accepted into the TCA cycle by a “feeder” reaction using the pyruvate dehydrogenase complex, resulting in acetyl-CoA and CO2. Provide the mechanism for this reaction utilizing the TPP cofactor. Include the roles of all cofactors.
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