PRINCIPLES OF LIFE
PRINCIPLES OF LIFE
3rd Edition
ISBN: 9781319017712
Author: HILLIS
Publisher: MAC HIGHER
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Chapter 9, Problem 1.1Q
Summary Introduction

To describe: The discovery of Chargaff that helped him in determining the structure of DNA.

Introduction: Deoxyribonucleic acid (DNA) is the hereditary material that transmits the genetic information from one generation to the next generation. It consists of two strands of polynucleotide chains that are wound around each other to form a double helix. It is composed of nucleotides, sugar, and phosphate.

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In 1950, the biochemist Erwin Chargaff and his colleagues found that DNA samples from different sources exhibited certain regularities with respect to the abundance of the different nucleotides. The Chargaff’s rule states that the amount of adenine is equal to the amount of thymine and the amount of guanine is equal to the amount of cytosine but the amount of other nucleotides was not equal. Thus, this relationship shows that the total amount of purine is equal to the total amount of pyrimidine.

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