Essential Cell Biology (Fourth Edition)
Essential Cell Biology (Fourth Edition)
4th Edition
ISBN: 9780815345251
Author: Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D. Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter
Publisher: W. W. Norton & Company
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Chapter 9, Problem 11Q

A.

Summary Introduction

To explain: Whether the positions of exons and introns in the β -globin gene could be deduced from the comparison of the human β -globin gene with the human β -globin cDNA.

Concept introduction:

Diagon plot is a graphical method commonly used in bioinformatics for the comparison of two biological sequences and to identify regions of close similarity between them. The plot compares two sequences by organizing one sequence on the X- axis and another on the Y-axis of the plot. When the sequences match at the same location, a dot is drawn at the corresponding position in the plot.

B.

Summary Introduction

To explain: The differences between the exons of human β -globin gene and mouse β -globin gene.

Concept introduction:

Diagon plot is a graphical method commonly used in bioinformatics for the comparison of two biological sequences and to identify regions of close similarity between them. The plot compares two sequences by organizing one sequence on the X- axis and another on the Y-axis of the plot. When the sequences match at the same location, a dot is drawn at the corresponding position in the plot.

C.

Summary Introduction

To explain: Whether there is any sequence similarity between the human and mouse β -globin genes that lie outside the exons. If so, identify its location and explain its preservation during evolution.

Concept introduction:

Diagon plot is a graphical method commonly used in bioinformatics for the comparison of two biological sequences and to identify regions of close similarity between them. The plot compares two sequences by organizing one sequence on the X- axis and another on the Y-axis of the plot. When the sequences match at the same location, a dot is drawn at the corresponding position in the plot.

D.

Summary Introduction

To explain:  Whether the mouse or human gene undergoes a change of intron length during their evolutionary divergence.

Concept introduction:

Diagon plot is a graphical method commonly used in bioinformatics for the comparison of two biological sequences and to identify regions of close similarity between them. The plot compares two sequences by organizing one sequence on the X- axis and another on the Y-axis of the plot. When the sequences match at the same location, a dot is drawn at the corresponding position in the plot.

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