Laboratory Manual for Anatomy and Physiology, 6e Loose-Leaf Print Companion
6th Edition
ISBN: 9781119304142
Author: Connie Allen, Valerie Harper
Publisher: WILEY
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Chapter 9, Problem 10UYK
Summary Introduction
Introduction: The vertebral column is a curved and flexible structure protecting the spinal cord. It provides a point of attachment for abdominal muscles and the back muscles. It articulates with the cranium, ribs, and pelvis. There are five regions present in the vertebral column.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 9 Solutions
Laboratory Manual for Anatomy and Physiology, 6e Loose-Leaf Print Companion
Ch. 9 - Prob. 1.1BGLCh. 9 - Label the bones forming the orbit of the eye in...Ch. 9 - Label the bone markings listed in Figures...Ch. 9 - Label the 4 paranasal sinuses in Figure 9.11.
Ch. 9 - Label the bones and cartilage of the nasal septum...Ch. 9 - Label the fontanels in Figures 9.13(a)–(c).
Ch. 9 - Locate the hyoid bone in Figure 9.8.
Ch. 9 - Label the 5 regions of the vertebral column in...Ch. 9 - Label the 4 normal curvatures in Figure 9.15.
Ch. 9 - Locate the parts of a typical vertebra shown in...
Ch. 9 - Label the parts of an atlas, axis, and cervical...Ch. 9 - Label the parts of a thoracic vertebra in Figure...Ch. 9 - Label the parts of articulated vertebrae in Figure...Ch. 9 - Label the parts of the sacrum and coccyx in Figure...Ch. 9 - Label the parts of a thoracic vertebra in Figure...Ch. 9 - Label the bones forming the orbit of the eye in...Ch. 9 - Label the parts of a rib and its articulation with...Ch. 9 - __________ Middle nasal concha
Ch. 9 - __________ Foramen magnum
Ch. 9 - Prob. 3CBSMCh. 9 - Prob. 4CBSMCh. 9 - __________ Sella turcica
Ch. 9 - Prob. 6CBSMCh. 9 - __________ Crista galli
Ch. 9 - __________ Greater wing
Ch. 9 - __________ Mastoid process
Ch. 9 - __________ Occipital condyle
Ch. 9 - __________ Optic foramen
Ch. 9 - __________ Mandibular fossa
Ch. 9 - __________ Olfactory foramina
Ch. 9 - __________ Supraorbital ridges
Ch. 9 - __________ Lacrimal fossa
Ch. 9 - __________ Zygomatic process
Ch. 9 - __________ Styloid process
Ch. 9 - __________ Palatine process
Ch. 9 - __________ Mental foramina
Ch. 9 - __________ Carotid foramen (canal)
Ch. 9 - __________ Condylar processes (mandibular...Ch. 9 - ____________________ Form the TMJ
Ch. 9 - ____________________ Form the TMJ
Ch. 9 - ____________________ Opening for carotid artery
Ch. 9 - Prob. 25CBSMCh. 9 - __________ Holes for cranial nerve I (olfactory...Ch. 9 - ____________________ Holes for cranial nerve II...Ch. 9 - ____________________ Opening through which the...Ch. 9 - ____________________ Anterior part of hard palate
Ch. 9 - ____________________ Rounded processes on skull...Ch. 9 - ____________________ Tooth sockets
Ch. 9 - ____________________ Form zygomatic arch
Ch. 9 - __________ Form zygomatic arch
Ch. 9 - ____________________ Protects the pituitary gland
Ch. 9 - __________ Softens jolts to the vertebral column
Ch. 9 - Prob. 2VCTCh. 9 - __________ Bony protection for thoracic organs
Ch. 9 - __________ First cervical vertebra
Ch. 9 - __________ Second cervical vertebra
Ch. 9 - __________ Articulates with rib posteriorly
Ch. 9 - __________ Tailbone
Ch. 9 - __________ Encloses and protects the spinal cord
Ch. 9 - __________ Primary curvatures
Ch. 9 - __________ Primary curvatures
Ch. 9 - __________ Secondary curvatures
Ch. 9 - __________ Secondary curvatures
Ch. 9 - __________ Formed by the fusion of pedicles and...Ch. 9 - __________ Passageway for vertebral arteries in...Ch. 9 - __________ Name the 4 parts of the thoracic cage
Ch. 9 - __________ Name the 4 parts of the thoracic cage
Ch. 9 - __________ Name the 4 parts of the thoracic cage
Ch. 9 - __________ Name the 4 parts of the thoracic cage
Ch. 9 - __________ Name the 3 bones of the sternum
Ch. 9 - __________ Name the 3 bones of the sternum
Ch. 9 - __________ Name the 3 bones of the sternum
Ch. 9 - __________ Concave depression in superior surface...Ch. 9 - ________. False ribs
Ch. 9 - ________. True ribs
Ch. 9 - ________. Floating ribs
Ch. 9 - __________ Space between ribs
Ch. 9 - __________ A special feature present on the...Ch. 9 - __________ Special features present on the...Ch. 9 - __________ Special features present on the...Ch. 9 - __________ Special features present on the...Ch. 9 - __________ A part of the rib that articulates with...Ch. 9 - __________ A part of the rib that articulates with...Ch. 9 - __________ The odontoid process is a part of which...Ch. 9 - __________ The suture that joins the occipital...Ch. 9 - Prob. 2OMASCh. 9 - Prob. 3OMASCh. 9 - Prob. 4OMASCh. 9 - Prob. 5OMASCh. 9 - Prob. 6OMASCh. 9 - Prob. 7OMASCh. 9 - Identify the bones and bone markings in Figure...Ch. 9 -
__________ (bone marking)
Ch. 9 -
__________ (bone)
Ch. 9 -
__________ (bone)
Ch. 9 -
__________ (bone)
Ch. 9 -
__________ (bone)
Ch. 9 -
__________ (bone marking)
Ch. 9 -
__________ (bone marking)
Ch. 9 -
__________ (bone marking)
Ch. 9 -
__________ (bone marking)
Ch. 9 -
__________ (space between bones)
Ch. 9 -
__________ (bone)
Ch. 9 -
__________ (bone)
Ch. 9 -
__________ (sinus)
Ch. 9 -
__________ (bone marking in sphenoid)
Ch. 9 -
__________ (opening)
Ch. 9 -
________________ (bone marking)
Ch. 9 -
________________ (bone marking)
Ch. 9 -
________________ (bone sinus)
Ch. 9 -
________________ (bone marking)
Ch. 9 -
________________ (bone)
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