Chapter 9, Problem 10P

Interpretation Introduction

(a)

Interpretation:

The residue in the active site of elastase that is most likely to form a covalent bond with the aldehyde is to be stated.

Concept introduction:

The organic compounds that contain amine $\left({\text{-NH}}_{\text{2}}\right)$ and carboxyl $\left(\text{-COOH}\right)$ functional groups with a side chain $\left(\text{-R}\right)$ are known as amino acids. Amino acids consist of both positive as well negative groups in their structure and are called as ampholytes. The small chain of amino acids that relates to the help of the amide bonds is known as peptide. A peptide possesses the covalent bonds which are formed by the reaction of carboxyl group $\left(\text{COOH}\right)$ that is present on one amino acid with the amino $\left({\text{-NH}}_2\right)$ group present on the other amino acid.

Interpretation Introduction

(b)

Interpretation:

The type of covalent link that would be formed between residue and aldehyde is to be identified.

Concept introduction:

Acetal is an organic compound with general formula $\text{RHC}{\left(\text{OR'}\right)}_2$. The two alkoxy groups $\left(\text{OR'}\right)$ are bonded with terminal carbon atom and the $\text{R'}$ group can be same or different. Hemiacetal is an organic compound with general formula $\text{RHC}\left(\text{OH}\right)\text{OR'}$. The $\text{OH}$ and $\text{OR'}$ groups are present on the terminal carbon atom.