Biology: Concepts and Investigations
3rd Edition
ISBN: 9780073525549
Author: Mariëlle Hoefnagels Dr.
Publisher: McGraw-Hill Education
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Concept explainers
Question
Chapter 8.3, Problem 2MC
Summary Introduction
To enlist:
The events of binary fission.
Concept introduction:
Binary fission is the process in which the genetic material duplicates itself within the cell and then the cell divides into two daughter nuclei.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 8 Solutions
Biology: Concepts and Investigations
Ch. 8.1 - Explain the roles of mitotic cell division,...Ch. 8.1 - Prob. 2MCCh. 8.2 - Prob. 1MCCh. 8.2 - Prob. 2MCCh. 8.2 - Prob. 3MCCh. 8.2 - Prob. 4MCCh. 8.2 - Prob. 5MCCh. 8.3 - Which cell types divide by binary fission?Ch. 8.3 - Prob. 2MCCh. 8.4 - Prob. 1MC
Ch. 8.4 - Prob. 2MCCh. 8.5 - Prob. 1MCCh. 8.5 - Prob. 2MCCh. 8.5 - Prob. 3MCCh. 8.5 - Distinguish between mitosis and cytokinesis.Ch. 8.6 - Prob. 1MCCh. 8.6 - Prob. 2MCCh. 8.6 - Prob. 3MCCh. 8.6 - Prob. 4MCCh. 8.6 - Prob. 5MCCh. 8.6 - Prob. 6MCCh. 8.6 - Prob. 7MCCh. 8.7 - Prob. 1MCCh. 8.7 - Prob. 2MCCh. 8.8 - Prob. 1MCCh. 8.8 - Prob. 2MCCh. 8 - Prob. 1MCQCh. 8 - A DNA molecule is placed in a test tube containing...Ch. 8 - Prob. 3MCQCh. 8 - Prob. 4MCQCh. 8 - Prob. 5MCQCh. 8 - Prob. 1WIOCh. 8 - Prob. 2WIOCh. 8 - Write and explain an analogy for each of these DNA...Ch. 8 - Prob. 4WIOCh. 8 - Obtain a rubber band and twist it as m any times...Ch. 8 - Prob. 6WIOCh. 8 - Prob. 7WIOCh. 8 - Prob. 8WIOCh. 8 - Describe what will happen to a cell if interphase...Ch. 8 - List the ways that binary fission is similar to...Ch. 8 - Prob. 11WIOCh. 8 - Prob. 13WIOCh. 8 - Prob. 12WIOCh. 8 - Prob. 14WIOCh. 8 - Prob. 15WIOCh. 8 - Prob. 1PITCh. 8 - Prob. 2PITCh. 8 - Prob. 3PIT
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