ANAT & PHYS: AN INTEG APPR >LL< W/CONNEC
4th Edition
ISBN: 9781266688072
Author: McKinley
Publisher: MCG CUSTOM
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Chapter 8.1, Problem 2WDYL
What is the difference between a foramen and a fissure?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 8 Solutions
ANAT & PHYS: AN INTEG APPR >LL< W/CONNEC
Ch. 8.1 - What is the general function of the axial...Ch. 8.1 - What is the difference between a foramen and a...Ch. 8.2 - Prob. 3WDYLCh. 8.2 - Prob. 4WDYLCh. 8.2 - What bones form the middle cranial fossa, and...Ch. 8.2 - Prob. 6WDYLCh. 8.2 - Prob. 7WDYLCh. 8.2 - In which four bones are the paranasal sinuses...Ch. 8.3 - Prob. 9WDYLCh. 8.4 - Prob. 10WDYL
Ch. 8.4 - What are the two largest fontanelles, and when do...Ch. 8.5 - Prob. 12WDYLCh. 8.5 - What are the secondary curves, and when do they...Ch. 8.5 - Compare the locations and functions of the...Ch. 8.5 - Prob. 15WDYLCh. 8.6 - Prob. 16WDYLCh. 8.6 - Prob. 17WDYLCh. 8.7 - Prob. 18WDYLCh. 8.8 - How do the sternal end and acromial end of the...Ch. 8.8 - Prob. 20WDYLCh. 8.9 - Prob. 21WDYLCh. 8.9 - Prob. 22WDYLCh. 8.9 - Prob. 23WDYLCh. 8.9 - Describe how the radius and ulna are positioned...Ch. 8.9 - Prob. 25WDYLCh. 8.10 - What three bones fuse to form the os coxae?Ch. 8.10 - Prob. 27WDYLCh. 8.10 - How is the pelvic inlet distinguished from the...Ch. 8.10 - Prob. 29WDYLCh. 8.10 - What are some differences in the symphysial...Ch. 8.11 - Prob. 31WDYLCh. 8.11 - Prob. 32WDYLCh. 8.11 - What are some bony features that are similar or...Ch. 8.11 - Prob. 34WDYLCh. 8.11 - Prob. 35WDYLCh. 8.11 - Prob. 36WDYLCh. 8.12 - Prob. 37WDYLCh. 8 - Prob. 1DYKBCh. 8 - Which bone marking is matched with its correct...Ch. 8 - The frontal and parietal bones articulate at the...Ch. 8 - Prob. 4DYKBCh. 8 - Prob. 5DYKBCh. 8 - Prob. 6DYKBCh. 8 - Prob. 7DYKBCh. 8 - Prob. 8DYKBCh. 8 - The femur articulates with the tibia at the a....Ch. 8 - Prob. 10DYKBCh. 8 - Prob. 11DYKBCh. 8 - Prob. 12DYKBCh. 8 - What are the functions of the paranasal sinuses?Ch. 8 - Prob. 14DYKBCh. 8 - Describe similarities and differences among true,...Ch. 8 - Compare and contrast the anatomic and functional...Ch. 8 - What are the primary similarities and differences...Ch. 8 - Prob. 18DYKBCh. 8 - Prob. 19DYKBCh. 8 - Prob. 20DYKBCh. 8 - Prob. 1CALCh. 8 - Prob. 2CALCh. 8 - Prob. 3CALCh. 8 - Prob. 4CALCh. 8 - Use the following paragraph to answer questions...Ch. 8 - Prob. 1CSLCh. 8 - Prob. 2CSLCh. 8 - Forensic anthropologists are investigating...
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