The necessity of conducting TLC in a closed chamber and saturation of interior with vapor of the solvent should be determined. Concept introduction: Thin layer chromatography works on the basic principle of separation of the constituents of the sample based on its interaction with the mobile and the stationary phase. The sample depending on the extent of its polarity gets separated on the stationary phase under the influence of the mobile phase.

Question

Q2: Ranking Acidity a) Rank the labeled protons in the following molecule in order of increasing pKa. Briefly explain the ranking. Use Table 2.2 as reference. Ha Нь HC H-N Ha OHe b) Atenolol is a drug used to treat high blood pressure. Which of the indicated N-H bonds is more acidic? Explain. (Hint: use resonance structures to help) Name the functional groups on atenolol. H H-N atenolol Ν H-N OH Н

Answer 1

Question

Chapter 8, Problem 8Q

Interpretation Introduction

Interpretation:

The necessity of conducting TLC in a closed chamber and saturation of interior with vapor of the solvent should be determined.

Concept introduction:

Thin layer chromatography works on the basic principle of separation of the constituents of the sample based on its interaction with the mobile and the stationary phase. The sample depending on the extent of its polarity gets separated on the stationary phase under the influence of the mobile phase.

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Q2: Ranking Acidity a) Rank the labeled protons in the following molecule in order of increasing pKa. Briefly explain the ranking. Use Table 2.2 as reference. Ha Нь HC H-N Ha OHe b) Atenolol is a drug used to treat high blood pressure. Which of the indicated N-H bonds is more acidic? Explain. (Hint: use resonance structures to help) Name the functional groups on atenolol. H H-N atenolol Ν H-N OH Н

Answer d, e, and f

If the rotational constant of a molecule is B = 120 cm-1, it can be stated that the transition from 2←1:a) gives rise to a line at 120 cm-1b) is a forbidden transitionc) gives rise to a line at 240 cm-1d) gives rise to a line at 480 cm-1