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Essentials of Human Anatomy & Physiology Laboratory Manual (6th Edition)
6th Edition
ISBN: 9780321947918
Author: Elaine N. Marieb
Publisher: PEARSON
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Chapter 8, Problem 45CAQ
Summary Introduction
To analyze:
Aiden is a 4-year-old albino boy who is brought to an ophthalmologist for a routine eye checkup. The effect of albinism on normal vision.
Introduction:
Albinism is a genetic disorder that results in less or no production of pigment in the cells of the skin, hair, and eyes. The two types of albinism are oculocutaneous albinism, which affects the production of pigment in the skin, hair, and eyes and ocular albinism, which affects pigment production in the eyes only.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 8 Solutions
Essentials of Human Anatomy & Physiology Laboratory Manual (6th Edition)
Ch. 8 - More than one choice may apply. Which of the...Ch. 8 - More than one choice may apply. Identify the...Ch. 8 - Prob. 3MCCh. 8 - Which cranial nerve controls contraction of the...Ch. 8 - The cornea is nourished by a. corneal blood...Ch. 8 - When the eye focuses for far vision, a. the lens...Ch. 8 - Convergence a. requires contraction of the medial...Ch. 8 - Prob. 8MCCh. 8 - Prob. 9MCCh. 8 - Prob. 10MC
Ch. 8 - Prob. 11SAECh. 8 - Prob. 12SAECh. 8 - 13. Diagram and label the internal structures of...Ch. 8 - Prob. 14SAECh. 8 - Prob. 15SAECh. 8 - 16. What is the blind spot, and why is it so...Ch. 8 - What name is given to the structure that controls...Ch. 8 - What is the fovea centralis, and why is it...Ch. 8 - Prob. 19SAECh. 8 - Describe the difference between the photopupillary...Ch. 8 - 21. Define hyperopia, myopia, and emmetropia.
Ch. 8 - Prob. 22SAECh. 8 - Prob. 23SAECh. 8 - Prob. 24SAECh. 8 - Many students struggling through mountains of...Ch. 8 - Prob. 26SAECh. 8 - Prob. 27SAECh. 8 - Prob. 28SAECh. 8 - Prob. 29SAECh. 8 - Prob. 30SAECh. 8 - Prob. 31SAECh. 8 - Prob. 32SAECh. 8 - Prob. 33SAECh. 8 - Which special sense requires the most learning?Ch. 8 - 35. For each of the following descriptions,...Ch. 8 - Prob. 36CAQCh. 8 - Prob. 37CAQCh. 8 - Prob. 38CAQCh. 8 - Brandon suffered a ruptured artery in his middle...Ch. 8 - Prob. 40CAQCh. 8 - Kathy visits her Optician as she has been...Ch. 8 - 42. Julie and her father love to find the...Ch. 8 - Prob. 43CAQCh. 8 - 44. Mrs. Garson has an immune disorder that causes...Ch. 8 - Prob. 45CAQ
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