The number of doublings that will take place before the normal cells cease to divide and its consistency with the telomerase hypothesis. Introduction: Cancer can be of different types depending upon the type of cells, organ affected, and stage. The spreading of cancer to other places in the body is called metastasis. Cancer can be defined as the uncontrolled growth and proliferation of cells that compete with the normal cells for nutrition, space and eventually cause the death of normal cells

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Chapter 8, Problem 2IA

a.

Summary Introduction

To determine: The number of doublings that will take place before the normal cells cease to divide and its consistency with the telomerase hypothesis.

Introduction: Cancer can be of different types depending upon the type of cells, organ affected, and stage. The spreading of cancer to other places in the body is called metastasis. Cancer can be defined as the uncontrolled growth and proliferation of cells that compete with the normal cells for nutrition, space and eventually cause the death of normal cells

b.

Summary Introduction

To determine: The number of doubling that can take place in telomerase plus cell lines after which they fail to divide.

Introduction: The loss of telomere DNA restrains the ability of human cells to proliferate. The telomeres are present at the end of the chromosomes and contain repetitive DNA sequences. These sequences are shortened with time, and the telomeres length reduces, which takes place with aging.

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