Biology: Concepts and Investigations
Biology: Concepts and Investigations
4th Edition
ISBN: 9780078024207
Author: Mariëlle Hoefnagels Dr.
Publisher: McGraw-Hill Education
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Chapter 8, Problem 10WIO
Summary Introduction

To discuss:

The points before deciding whether to recommend that a cancer-stricken relative should eat more ginger.

Concept introduction:

Cancer is collectively a group of diseases in which abnormal cell growth occurs and it has the potential to infect or spread to other body parts. Cancer is one of the two types of cancer; malignant and benign. Tumor growth is linked with inflammation and oxidative stress. Thus, anti-inflammatory and anti-oxidative properties of ginger could play a role in cancer prevention.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
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