How calcitriol is synthesized and the mechanism by which it supports or raises blood calcium level. Introduction: Mineralization is a process (crystallization) that deposits phosphate, calcium, and other ions (from blood plasma) in the tissues of the bone as hydroxyapatite. This process is initiated by the osteoblast by laying collagen fibers on the surface of the osteon. These fibers are coated with minerals that make the matrix hard. Only if the concentration of the products (of above minerals) in the plasma reaches the critical value (solubility product), the hydroxyapatite is formed. Sometimes, calcification is repressed by some inhibitors found in the tissue. This inhibitor is deactivated by osteoblast, and it enables the precipitation of the salt in the matrix of the bone. The initially formed crystals perform like a “seed of crystals” that attract more phosphate and calcium from the plasma.

Question

Want to see the full answer?

Answer 1

Question

Chapter 7.4, Problem 5AYLO

Summary Introduction

To discuss:

How calcitriol is synthesized and the mechanism by which it supports or raises blood calcium level.

Introduction:

Mineralization is a process (crystallization) that deposits phosphate, calcium, and other ions (from blood plasma) in the tissues of the bone as hydroxyapatite. This process is initiated by the osteoblast by laying collagen fibers on the surface of the osteon. These fibers are coated with minerals that make the matrix hard. Only if the concentration of the products (of above minerals) in the plasma reaches the critical value (solubility product), the hydroxyapatite is formed. Sometimes, calcification is repressed by some inhibitors found in the tissue. This inhibitor is deactivated by osteoblast, and it enables the precipitation of the salt in the matrix of the bone. The initially formed crystals perform like a “seed of crystals” that attract more phosphate and calcium from the plasma.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

yu yeuwyuyuierydtgcygucygzycghjcygyugfyudguygcywgduycgyudgs yg

According to a recent study, 1 out of 50,000 people will be diagnosed with cystic fibrosis. Cystic fibrosis can be caused by a mutant form of the CFTR gene (dominant gene symbol is F and mutant is f). A. Using the rate of incidence above, what is the frequency of carriers of the cystic fibrosis allele for CFTR in the US? (3 pts) B. In a clinical study, 400 people from the population mentioned in (A.) were genotyped for BRCA1 Listed below are the results. Are these results in Hardy- Weinberg equilibrium? Use Chi Square to show whether or not they are. (3 pts) # of women BRCA1 genotype BB 390 Bb bb 12pt v 10 0 V Paragraph B IUA BIUA > V T² v <

Case Study—Ella Ella has a family history of diabetes. She wants to follow a healthful eating pattern that can lower her risk for developing this condition. Her dietitian recommends a goal of 450 to 600 kcal per meal and advises Ella to follow the Acceptable Macronutrient Distribution Range (AMDR) for carbohydrates and the Dietary Guidelines for Americans 2015-2020, which recommend limiting added sugar. She also recommends that Ella choose whole grains rather than processed grains. Ella decides to pack a lunch to take to work every day. This morning she’s making a sandwich for her lunch. Categories of Sandwich Options (Top of the screen) Breads Spreads Cheeses Vegetables Proteins Specific food items to select White Bread 6-inches Honey Mustard Provolone LettuceTomatoBell Peppers Turkey Part A - Reading Nutrition Facts Panels for Total Kilocalories How many total kilocalories are in Ella’s sandwich? _______ kcal ? Part B - Reading Nutrition Facts Panels for…