EBK SEELEY'S ANATOMY & PHYSIOLOGY
11th Edition
ISBN: 8220102807433
Author: VanPutte
Publisher: YUZU
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Chapter 7, Problem 7CT
On the basis of the bone structure of the lower limb, explain why it is easier to turn the foot medially (sole of the foot facing toward the midline of the body) than laterally. Why is it easier to bend the wrist medially than laterally?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 7 Solutions
EBK SEELEY'S ANATOMY & PHYSIOLOGY
Ch. 7.1 - How are rounded and sharp projections, and...Ch. 7.1 - What does each of the following terms mean:...Ch. 7.1 - What are the two anatomical portions of the...Ch. 7.2 - What are the parts and general functions of the...Ch. 7.2 - Name the four major sutures of the skull and the...Ch. 7.2 - List the seven bones that form the orbit of the...Ch. 7.2 - What is a sinus? What are the functions of...Ch. 7.2 - Name the bones and cartilage that compose the...Ch. 7.2 - What bones form the hard palate, and what is the...Ch. 7.2 - What structure allows the brains tern to Connect...
Ch. 7.2 - Prob. 11AYPCh. 7.2 - What structure allows sound waves to reach the...Ch. 7.2 - Prob. 13AYPCh. 7.2 - Prob. 14AYPCh. 7.2 - Prob. 15AYPCh. 7.2 - Prob. 16AYPCh. 7.2 - Prob. 17AYPCh. 7.2 - Name the four major curvatures of the adult...Ch. 7.2 - Prob. 19AYPCh. 7.2 - Prob. 20AYPCh. 7.2 - Prob. 21AYPCh. 7.2 - Prob. 22AYPCh. 7.2 - Name and give the number of vertebrae in each of...Ch. 7.2 - What is the function of the thoracic cage?...Ch. 7.2 - Prob. 25AYPCh. 7.2 - What are the ports of the sternum? Name the...Ch. 7.3 - Describe how the upper and lower limbs are...Ch. 7.3 - Prob. 28AYPCh. 7.3 - Prob. 29AYPCh. 7.3 - Identify the bones of the upper limb, and describe...Ch. 7.3 - Prob. 31AYPCh. 7.3 - What is the function of the radial tuberosity? The...Ch. 7.3 - Prob. 33AYPCh. 7.3 - Prob. 34AYPCh. 7.3 - Prob. 35AYPCh. 7.3 - Describe the structure of the hip bone. What...Ch. 7.3 - Name the important sites of muscle attachment on...Ch. 7.3 - Prob. 38AYPCh. 7.3 - Prob. 39AYPCh. 7.3 - Prob. 40AYPCh. 7.3 - Prob. 41AYPCh. 7.3 - Prob. 42AYPCh. 7.3 - Prob. 43AYPCh. 7.3 - Prob. 44AYPCh. 7.3 - List the three arches of the foot, and describe...Ch. 7 - Which of these is pan of the appendicular...Ch. 7 - Prob. 2RACCh. 7 - Prob. 3RACCh. 7 - Prob. 4RACCh. 7 - The mandible articulates with the skull at the a....Ch. 7 - Prob. 6RACCh. 7 - The major blood supply to the brain enters thought...Ch. 7 - Prob. 8RACCh. 7 - Which of these bones is not in contact with the...Ch. 7 - A herniated disk occurs when a. the annulus...Ch. 7 - Prob. 11RACCh. 7 - Prob. 12RACCh. 7 - Which of these statements concerning ribs is...Ch. 7 - Prob. 14RACCh. 7 - Prob. 15RACCh. 7 - Prob. 16RACCh. 7 - Prob. 17RACCh. 7 - Prob. 18RACCh. 7 - When comparing the pectoral girdle with the pelvic...Ch. 7 - When comparing a male pelvis with a female pelvis,...Ch. 7 - Prob. 21RACCh. 7 - Prob. 1CTCh. 7 - Prob. 2CTCh. 7 - If the vertebral column is forcefully rotated,...Ch. 7 - Prob. 4CTCh. 7 - A paraplegic person develops decubitus ulcers...Ch. 7 - Why do women tend to suffer more knee pain and...Ch. 7 - On the basis of the bone structure of the lower...Ch. 7 - Prob. 8CT
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