IA MODIFIED MASTERING BIOLOGY WITH E TEX
12th Edition
ISBN: 9780136781752
Author: Urry
Publisher: PEARSON
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Chapter 7, Problem 7.5CR
Which type of endocytosis involves the binding of specific substances in the extracellular fluid to membrane proteins? What does this type of transport enable a cell to do?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 7 Solutions
IA MODIFIED MASTERING BIOLOGY WITH E TEX
Ch. 7.1 - VISUAL SKILLS Carbohydrates are attached to...Ch. 7.1 - Prob. 2CCCh. 7.2 - What property allows O2 and CO2 to cross a lipid...Ch. 7.2 - VISUAL SKILLS Examine Figure 7.2. Why is a...Ch. 7.2 - MAKE CONNECTIONS Aquaporins exclude passage of...Ch. 7.3 - Prob. 1CCCh. 7.3 - WHAT IF? If a Paramecium swims from a hypotonic...Ch. 7.4 - Prob. 1CCCh. 7.4 - Prob. 2CCCh. 7.4 - MAKE CONNECTIONS Review the characteristics of...
Ch. 7.5 - As a cell grows, its plasma membrane expands. Does...Ch. 7.5 - DRAW IT Return to Figure 7.9, and circle a patch...Ch. 7.5 - Prob. 3CCCh. 7 - In what ways are membranes crucial to life?Ch. 7 - How do aquaporins affect the permeability of a...Ch. 7 - What happens to a cell placed in a hypertonic...Ch. 7 - ATP is not directly involved in the functioning of...Ch. 7 - Which type of endocytosis involves the binding of...Ch. 7 - In what way do the membranes of a eukaryotic Cell...Ch. 7 - According to the fluid mosaic model of membrane...Ch. 7 - Which of the following factors would tend to...Ch. 7 - Which of the following processes includes all the...Ch. 7 - Prob. 5TYUCh. 7 - DRAW IT An artificial "cell" consisting of an...Ch. 7 - EVOLUTION CONNECTION Paramecium and other...Ch. 7 - Prob. 8TYUCh. 7 - SCIENCE, TECHNOLOGY, AND SOCIETY Extensive...Ch. 7 - WRITE ABOUT A THEME: INTERACTIONS A human...Ch. 7 - SYNTHESIZE YOUR KNOWLEDGE In the supermarket,...
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