Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 7, Problem 2NST
Campomelic dysplasia (CMD1) is a congenital human syndrome featuring malformation of bone and cartilage. It is caused by an autosomal dominant mutation of a gene located on chromosome 17. Consider the following observations in sequence, and in each case, draw whatever appropriate conclusions are warranted.
- (a) Of those with the syndrome who are karyotypically 46, XY, approximately 75 percent are sex reversed, exhibiting a wide range of female characteristics.
- (b) The nonmutant form of the gene, called SOX9, is expressed in the developing gonad of the XY male, but not the XX female.
- (c) The SOX9 gene shares 71 percent amino acid coding sequence homology with the Y-linked SRY gene.
- (d) CMD1 patients who exhibit a 46, XX karyotype develop as females, with no gonadal abnormalities.
HINT: This problem asks you to apply the information presented in this chapter to a real-life example. The key to its solution is knowing that some genes are activated and produce their normal product as a result of expression of products of other genes found on different chromosomes.
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Campomelic dysplasia (CMD1) is a congenital humansyndrome featuring malformation of bone and cartilage.It is caused by an autosomal dominant mutation of agene located on chromosome 17. Consider the followingobservations in sequence, and in each case, draw whateverappropriate conclusions are warranted.(a) Of those with the syndrome who are karyotypically46,XY, approximately 75 percent are sex reversed,exhibiting a wide range of female characteristics.(b) The nonmutant form of the gene, called SOX9, isexpressed in the developing gonad of the XY male,but not the XX female.(c) The SOX9 gene shares 71 percent amino acid codingsequence homology with the Y-linked SRY gene.(d) CMD1 patients who exhibit a 46,XX karyotypedevelop as females, with no gonadal abnormalities.
Congenital hypertrichosis (CH) is a very rare X-linked
dominant inherited condition. CH is characterized by the
growth of dark hair over the body.
CH is so rare, only 50 cases have been identified since
the Middle Ages. The incidence of this condition is
considerably higher in a small Mexican village (from
which the partial pedigree below is derived) than the rest
of the human population.
I
II
III
Use the following information to answer
the two questions.
IV
D
II-4
8 9
IV-6
0=10~
11
1. Using appropriate nomenclature, identify the
genotypes for the following 2 individuals:
12 13
your response must include an appropriate
legend/key to identify allele symbols.
2. Show how a Punnett square (using the allele
symbols from the previous question) is used
to determine the probability in percent of
individuals III-11 and III-12 next offspring has CH?
Achondroplasia is an autosomal dominant disorder characterized by disproportionate short stature: the legs and arms of people with achondroplasia are short compared with the head and trunk. The disorder is due to a base substitution in the gene, located on the short arm of chromosome 4, that encodes fibroblast growth factor receptor 3 (FGFR3). Although achondroplasia is clearly inherited as an autosomal dominant trait, more than 80% of the people who have achondroplasia are born to parents with normal stature. This high percentage indicates that most cases are caused by newly arising mutations; these cases (not inherited from an affected parent) are referred to as sporadic. Studies have demonstrated that sporadic cases of achondroplasia are almost always caused by mutations inherited from the father (paternal mutations). In addition, the occurrence of achondroplasia is higher among the children of older fathers; approximately 50% of children with achondroplasia are born to fathers…
Chapter 7 Solutions
Concepts of Genetics (11th Edition)
Ch. 7 - Prob. 1NSTCh. 7 - Campomelic dysplasia (CMD1) is a congenital human...Ch. 7 - Carbon Copy (CC), the first car produced from a...Ch. 7 - Prob. 1CSCh. 7 - Prob. 2CSCh. 7 - Prob. 3CSCh. 7 - Prob. 4CSCh. 7 - HOW DO WE KNOW? In this chapter, we have focused...Ch. 7 - Review the Chapter Concepts list on p. 151. These...Ch. 7 - Prob. 3PDQ
Ch. 7 - Prob. 4PDQCh. 7 - Distinguish between the concepts of sexual...Ch. 7 - Contrast the XX/XY and XX/X0 modes of sex...Ch. 7 - Describe the major difference between sex...Ch. 7 - How do mammals, including humans, solve the dosage...Ch. 7 - The phenotype of an early-stage human embryo is...Ch. 7 - What specific observations (evidence) support the...Ch. 7 - Describe how nondisjunction in human female...Ch. 7 - An insect species is discovered in which the...Ch. 7 - When cows have twin calves of unlike sex...Ch. 7 - An attached-X female fly, XXY (see the Insights...Ch. 7 - Assume that on rare occasions the attached X...Ch. 7 - It has been suggested that any male-determining...Ch. 7 - What is a Barr body, and where is it found in a...Ch. 7 - Indicate the expected number of Barr bodies in...Ch. 7 - Define the Lyon hypothesis.Ch. 7 - Can the Lyon hypothesis be tested in a human...Ch. 7 - Predict the potential effect of the Lyon...Ch. 7 - Cat breeders are aware that kittens expressing the...Ch. 7 - Prob. 23PDQCh. 7 - Prob. 24PDQCh. 7 - Prob. 25PDQCh. 7 - Prob. 26PDQCh. 7 - In mice, the Sry gene (see Section 7.2) is located...Ch. 7 - The genes encoding the red-and...Ch. 7 - What is the role of the enzyme aromatase in sexual...Ch. 7 - In the wasp Bracon hebetor, a form of...Ch. 7 - Prob. 31ESPCh. 7 - In mice, the X-linked dominant mutation Testicular...Ch. 7 - When the cloned cat Carbon Copy (CC) was born (see...Ch. 7 - Prob. 34ESPCh. 7 - In chickens, a key gene involved in sex...Ch. 7 - Prob. 36ESP
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