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Chapter 6.5, Problem 2QC

Explain how compression, continuous pressure on a bone, and dietary factors influence bone remodeling.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
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Chapter 6 Solutions

Human Anatomy & Physiology Plus Mastering A&P with Pearson eText -- Access Card Package (2nd Edition) (What's New in Anatomy & Physiology)

Ch. 6.3 - What are primary and secondary bone, and how do...Ch. 6.3 - For each type of ossification: a. Does spongy bone...Ch. 6.3 - 5. Which type of ossification: a. involves a bone...Ch. 6.4 - What tissue type makes up the epiphyseal plate?Ch. 6.4 - How does bone grow in length from the epiphyseal...Ch. 6.4 - Prob. 3QCCh. 6.4 - Prob. 4QCCh. 6.4 - How is bone growth affected by the sex hormones...Ch. 6.5 - How do bone resorption and bone deposition differ?Ch. 6.5 - Explain how compression, continuous pressure on a...Ch. 6.5 - What role does parathyroid hormone play in calcium...Ch. 6.5 - 4. Walk through the basic steps of fracture...Ch. 6 - Which of the following is not a function of the...Ch. 6 - Match the following terms with the correct...Ch. 6 - Explain the differences between red bone marrow...Ch. 6 - 4. Mark the following statements about bone...Ch. 6 - Prob. 5CYRCh. 6 - 6. The branching pieces of bone in spongy bone...Ch. 6 - 7. Which bones form via intramembranous...Ch. 6 - Of the following statements, identify those that...Ch. 6 - What is the difference between a primary and...Ch. 6 - 10. The part of the epiphysis that does not...Ch. 6 - Long bones grow in length from the: a. diaphyseal...Ch. 6 - 12. Correctly order the following steps of bone...Ch. 6 - Explain the effect that the following hormones...Ch. 6 - Fill in the blanks. Bone deposition is carried out...Ch. 6 - Mark the following statements as true or false. If...Ch. 6 - 16. Which of the following influences bone...Ch. 6 - Correctly order the following steps of fracture...Ch. 6 - 1. Explain why a person who is wheelchair-bound or...Ch. 6 - 2. How could diseases of the kidney, skin, and/or...Ch. 6 - How could a disease that affects primarily...Ch. 6 - It used to be common practice in surgical fracture...Ch. 6 - Explain why young men who take anabolic steroids...Ch. 6 - Prob. 3AYKACh. 6 - Fouz Akkad is a 6-year-old girl who has been...
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