Microbiology: A Systems Approach
5th Edition
ISBN: 9781259706615
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
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Chapter 6.2, Problem 2AYP
Summarize arguments on both sides of the debate regarding the classification of viruses as living organisms.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 6 Solutions
Microbiology: A Systems Approach
Ch. 6.1 - Describe the significance of viruses being...Ch. 6.2 - Summarize arguments on both sides of the debate...Ch. 6.2 - Identify effective terms to describe the behavior...Ch. 6.3 - Prob. 4AYPCh. 6.3 - Describe the function and structure(s) of viral...Ch. 6.3 - Distinguish between enveloped and naked viruses.Ch. 6.3 - Prob. 7AYPCh. 6.3 - Compare and contrast the composition of a viral...Ch. 6.3 - Diagram the possible nucleic acid configurations...Ch. 6.4 - Develop two arguments against assigning species...
Ch. 6.4 - Demonstrate how family and genus names in viruses...Ch. 6.5 - Diagram the six-step life cycle of animal viruses.Ch. 6.5 - Define the term cytopathic effect and provide one...Ch. 6.5 - Provide examples of persistent and transforming...Ch. 6.5 - Provide a thorough description of lysogenic and...Ch. 6.6 - List the three principal purposes for cultivating...Ch. 6.6 - Describe three ways in which viruses are...Ch. 6.7 - Prob. 18AYPCh. 6.8 - Analyze the relative importance of viruses in...Ch. 6.8 - Prob. 20AYPCh. 6 - A virus is a tiny infectious a. cell. b. living...Ch. 6 - Viruses are known to infect a. plants. b....Ch. 6 - The nucleic acid of a virus is a. DNA only. b. RNA...Ch. 6 - The general steps in a viral multiplication cycle...Ch. 6 - Prob. 5MCQCh. 6 - In general, RNA viruses multiply in the cell ____,...Ch. 6 - Viruses cannot be cultivated in/on a. tissue...Ch. 6 - Clear patches in cell cultures that indicate sites...Ch. 6 - Label the parts of this virus. Identify the...Ch. 6 - Circle the viral infections from this list:...Ch. 6 - In lysogeny, viral DNA is inserted into the host...Ch. 6 - A viral capsid is composed of subunits called...Ch. 6 - The envelope of an animal virus is derived from...Ch. 6 - The nucleic acid of animal viruses enters the cell...Ch. 6 - Viruses that persist in the (host) cell and cause...Ch. 6 - Provide evidence in support of or refuting the...Ch. 6 - Summarize the unique properties of viruses and...Ch. 6 - Prob. 3CTQCh. 6 - Compare and contrast the processes of latency and...Ch. 6 - Use the Internet to search prion diseases, and...Ch. 6 - From chapter 2, figure 2.23: A virus containing...Ch. 6 - Prob. 1CM
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