Vander's Human Physiology
Vander's Human Physiology
15th Edition
ISBN: 9781259903885
Author: WIDMAIER, Eric P., Vander, Arthur J.
Publisher: Mcgraw-hill Education,
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Chapter 6, Problem 9RC
Summary Introduction

Introduction: In an adult, 40 to 50% body weight is contributed by skeletal muscles. The primary cells that form a skeletal muscle is the skeletal muscle fibers. Smooth muscle cells are fusiform shaped and small with the centrally located nucleus. They are located throughout the human body typically consisting of about 2% of the total body weight.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
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Vander's Human Physiology

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