FUNDAMENTALS OF BIOCHEM.-NEXTGEN ACCESS
FUNDAMENTALS OF BIOCHEM.-NEXTGEN ACCESS
5th Edition
ISBN: 9781119661450
Author: Voet
Publisher: WILEY
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Chapter 6, Problem 39CQ
Summary Introduction

To explain: The basis for this irreversibility in terms of the sequence of structural and binding changes in the GroEL/ES system.

Concept introduction: GroEL is a kind of molecular chaperons which is necessary for proper protein folding. GroEL has two U-shaped subunits which are arranged in the form of seven-membered rings. There are three domains present in GroEL/ES system such as equatorial, apical and intermediate domains. The nucleotide binding site is present in the equatorial domain. Apical domain has polypeptide binding site. These two domains are interconnected by the intermediate domain.

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