Chapter 6, Problem 1E

Summary Introduction

To draw: The cis peptide with groups that experience steric interference.

Concept introduction: The linkage between the linear sequences of amino acid residues by the covalent bond is called peptide bond. Most of the peptide bonds in proteins are in trans-configuration. Some of them attain cis-configuration. Steric interference is experienced by an atom as a result of the overlapping of electron clouds.

Answer to Problem 1E

Correct answer: Fig. 1 shows the cis peptide with groups that experience steric effects.

Pictorial representation: Fig. 1 shows the cis peptide with groups that experience steric interference.

Fig. 1: cis peptide with groups that experience steric interference.

Explanation of Solution

Fig. 1 shows the cis peptide with groups that experience steric effects. The cis peptide bonds are usually observed at proline and glycine. The steric hindrance causes this amino acid residue to occur in the outlier region at the Ramachandran plot.