BIOLOGY 12E CONNECT ACCESS CARD
12th Edition
ISBN: 9781264938513
Author: Raven
Publisher: MCG
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Textbook Question
Chapter 57, Problem 3A
If a pesticide is harmless at low concentrations (such as DDT) and used properly. how can it become a threat to nontargct organisms?
a. Because after exposure to DDT. some species develop allergic reactions even at low levels of exposure
b. Because DDT molecules can combine so that their concentration increases through time
c Because the concentration of chemicals such as DDT is increasingly concentrated at higher trophic levels
d. Because global warming and exposure to UV-B radiation renders molecules such as DDT increasingly potent
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 57 Solutions
BIOLOGY 12E CONNECT ACCESS CARD
Ch. 57.1 - Prob. 1LOCh. 57.1 - Prob. 2LOCh. 57.1 - Prob. 3LOCh. 57.2 - Prob. 1LOCh. 57.2 - Explain the primary factors that determine which...Ch. 57.3 - Prob. 1LOCh. 57.3 - Prob. 2LOCh. 57.3 - Prob. 3LOCh. 57.4 - Prob. 1LOCh. 57.4 - Prob. 2LO
Ch. 57.5 - Prob. 1LOCh. 57.5 - Differentiate between point-source pollution and...Ch. 57.5 - Prob. 3LOCh. 57.5 - Prob. 4LOCh. 57.6 - Prob. 1LOCh. 57.6 - Prob. 2LOCh. 57 - Prob. 1DACh. 57 - Prob. 2DACh. 57 - Prob. 1IQCh. 57 - Prob. 2IQCh. 57 - 1. The Coriolis effect a. drives the rotation of...Ch. 57 - What two factors are most important in biome...Ch. 57 - In a rain shadow, air is cooled as it rises and...Ch. 57 - Thermal stratification in a lake a. is not...Ch. 57 - Prob. 5UCh. 57 - Deep-sea hydrothermal vent communities a. get...Ch. 57 - Prob. 7UCh. 57 - Which of the following is a point source of...Ch. 57 - If the Earth were not tilted on its axis of...Ch. 57 - Prob. 2ACh. 57 - If a pesticide is harmless at low concentrations...Ch. 57 - Prob. 4ACh. 57 - Discuss how figure 58.1 explains the pattern...Ch. 57 - Prob. 2SCh. 57 - If the world has experienced global warming many...Ch. 57 - What can be done to prevent new diseases from...
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