ANAT.+PHYSIO.1-LAB.MAN. >CUSTOM<
20th Edition
ISBN: 9781264303106
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 5.5, Problem 26AYP
Summary Introduction
To write:
The kinds of sensory receptors are in the skin and their importance.
Introduction:
The skin is made up of two major tissue layers, the dermis and the epidermis. The epidermis is the superficial layer of the skin, consisting of stratified squamous epithelial tissue. The multiple cell layers of the epidermis protects against the potential damage from the abrasion on the skin's surface.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 5 Solutions
ANAT.+PHYSIO.1-LAB.MAN. >CUSTOM<
Ch. 5.1 - Provide on example for each function of the...Ch. 5.2 - From deepest to most superficial, name and...Ch. 5.2 - Prob. 3AYPCh. 5.2 - Prob. 4AYPCh. 5.2 - Prob. 5AYPCh. 5.2 - How do gentic factors, exposure to sunlight, and...Ch. 5.2 - How do carotene, blood flow, oxygen content, and...Ch. 5.2 - Prob. 8AYPCh. 5.2 - Prob. 9AYPCh. 5.2 - What are cleavage lines, and how are they related...
Ch. 5.3 - Name the types of tissue forming the subcutaneous...Ch. 5.3 - Prob. 12AYPCh. 5.3 - Prob. 13AYPCh. 5.4 - When and where are Ianugo, vellus, and found in...Ch. 5.4 - Prob. 15AYPCh. 5.4 - Prob. 16AYPCh. 5.4 - Describe the ports of a hair follicle. How the...Ch. 5.4 - Prob. 18AYPCh. 5.4 - Prob. 19AYPCh. 5.4 - Prob. 20AYPCh. 5.4 - Prob. 21AYPCh. 5.4 - Which glands of the skin are responsible for...Ch. 5.4 - Name the ports of a nail. Which Port produces most...Ch. 5.4 - Prob. 24AYPCh. 5.5 - In what ways does the skin provide protection?Ch. 5.5 - Prob. 26AYPCh. 5.5 - Prob. 27AYPCh. 5.5 - Prob. 28AYPCh. 5.5 - Prob. 29AYPCh. 5.6 - Prob. 30AYPCh. 5.7 - Compared with young skin, why is aged skin more...Ch. 5.7 - Prob. 32AYPCh. 5.7 - Prob. 33AYPCh. 5.7 - Prob. 34AYPCh. 5 - If a splinter penetrates the skin of the palm of...Ch. 5 - Prob. 2RACCh. 5 - Prob. 3RACCh. 5 - Prob. 4RACCh. 5 - Prob. 5RACCh. 5 - Prob. 6RACCh. 5 - Prob. 7RACCh. 5 - Prob. 8RACCh. 5 - Prob. 9RACCh. 5 - Prob. 10RACCh. 5 - Prob. 11RACCh. 5 - Prob. 12RACCh. 5 - Prob. 13RACCh. 5 - Prob. 14RACCh. 5 - Prob. 15RACCh. 5 - Smooth muscles that are attached to hair follicles...Ch. 5 - Prob. 17RACCh. 5 - For questions 17-19, match the type of gland with...Ch. 5 - Prob. 19RACCh. 5 - Prob. 20RACCh. 5 - Prob. 21RACCh. 5 - Prob. 22RACCh. 5 - Which of these processes increase (s) heat loss...Ch. 5 - Prob. 24RACCh. 5 - The skin of infants is more easily penetrated and...Ch. 5 - Melanocytes are found primarily in the stratum...Ch. 5 - The rare of water loss from the skin of a hand was...Ch. 5 - It has been several weeks since George has...Ch. 5 - Prob. 5CTCh. 5 - Why are your eyelshes not a foot long? Your...Ch. 5 - Pulling on hair can be quite painful, hyet cutting...Ch. 5 - A patient has an ingrown toenail, in which the...Ch. 5 - Defend or refute the following statement:...Ch. 5 - Harry, age 55, went to a health fair and had a PSA...
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