EBK CAMPBELL BIOLOGY
11th Edition
ISBN: 8220103613828
Author: Reece
Publisher: PEARSON
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Chapter 52, Problem 8TYU
Summary Introduction
Introduction: The earth rotates around a line (imaginary) that passes right through the north and the south poles of the planet. In normal condition earth rotates from west to east. It brings about change in the season, day lengths, solar radiation and the temperature. It also affects the local environment.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 52 Solutions
EBK CAMPBELL BIOLOGY
Ch. 52.1 - Explain how the sun's unequal heating of Earth's...Ch. 52.1 - What are some of the differences in microclimate...Ch. 52.1 - WHAT IF? Changes in Earth's climate at the end of...Ch. 52.1 - MAKE CONNECTIONS Focusing just on the effects of...Ch. 52.2 - Based on the climograph in Figure 52.10, what...Ch. 52.2 - Using Figure 52.12, identify the natural biome in...Ch. 52.2 - WHAT IF? If global warming increases average...Ch. 52.3 - Why are phytoplankton, and not benthic algae or...Ch. 52.3 - Prob. 2CCCh. 52.3 - MAKE CONNECTIONS As noted in Figure 52.15, the...
Ch. 52.4 - Give examples of human actions that could expand a...Ch. 52.4 - WHAT IF? You suspect that deer are restricting...Ch. 52.4 - MAKE CONNECTIONS Hawaiian silverswords under-went...Ch. 52.5 - Describe a scenario showing how ecological change...Ch. 52.5 - MAKE CONNECTIONS Commercial fisheries target...Ch. 52 - Suppose global air circulation suddenly reversed,...Ch. 52 - Prob. 52.2CRCh. 52 - Prob. 52.3CRCh. 52 - Interactions between organisms and the environment...Ch. 52 - Suppose humans introduced a species to a new...Ch. 52 - Level 1: Knowledge/Comprehension 1. Which of the...Ch. 52 - Which lake zone would be absent in a very shallow...Ch. 52 - Which of the following is characteristic of most...Ch. 52 - The oceans affect the biosphere in all of the...Ch. 52 - Which statement about dispersal is false? (A)...Ch. 52 - When climbing a mountain, we can observe...Ch. 52 - Prob. 7TYUCh. 52 - Prob. 8TYUCh. 52 - Prob. 9TYUCh. 52 - EVOLUTION CONNECTION Discuss how the distribution...Ch. 52 - SCIENTIFIC INQUIRY Jens Clausen and colleagues, at...Ch. 52 - WRITE ABOUT A THEME: INTERACTIONS Global warming...Ch. 52 - SYNTHESIZE YOUR KNOWLEDGE If you were to hike up...
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